Literature DB >> 32297626

A caged E3 ligase ligand for PROTAC-mediated protein degradation with light.

Cyrille S Kounde1, Maria M Shchepinova1, Charlie N Saunders1, Marcel Muelbaier2, Mark D Rackham3, John D Harling4, Edward W Tate1.   

Abstract

With the intent of achieving greater spatiotemporal control of PROTAC-induced protein degradation, a light-activated degrader was designed by photocaging an essential E3 ligase binding motif in a BRD4 targeting PROTAC. Proteolysis was triggered only after a short irradiation time, the kinetics of which could be monitored by live-cell video microscopy.

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Year:  2020        PMID： 32297626     DOI： 10.1039/d0cc00523a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  19 in total

Review 1.  Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic.

Authors:  Zhenyi Hu; Craig M Crews
Journal:  Chembiochem       Date:  2021-09-23       Impact factor: 3.461

Review 2.  Novel Design Strategies to Enhance the Efficiency of Proteolysis Targeting Chimeras.

Authors:  Chunlong Zhao; Frank J Dekker
Journal:  ACS Pharmacol Transl Sci       Date:  2022-08-22

Review 3.  PROTACs: great opportunities for academia and industry (an update from 2020 to 2021).

Authors:  Ming He; Chaoguo Cao; Zhihao Ni; Yongbo Liu; Peilu Song; Shuang Hao; Yuna He; Xiuyun Sun; Yu Rao
Journal:  Signal Transduct Target Ther       Date:  2022-06-09

Review 4.  Proteolysis-targeting chimera (PROTAC) delivery system: advancing protein degraders towards clinical translation.

Authors:  Yu Chen; Ira Tandon; William Heelan; Yixin Wang; Weiping Tang; Quanyin Hu
Journal:  Chem Soc Rev       Date:  2022-07-04       Impact factor: 60.615

Review 5.  Major Advances in Emerging Degrader Technologies.

Authors:  Hang Luo; Li Wu; Yujian He; Chong Qin; Xinjing Tang
Journal:  Front Cell Dev Biol       Date:  2022-06-22

6.  Traceless Staudinger ligation enabled parallel synthesis of proteolysis targeting chimera linker variants.

Authors:  Troy A Bemis; James J La Clair; Michael D Burkart
Journal:  Chem Commun (Camb)       Date:  2021-01-06       Impact factor: 6.222

7.  Cancer Selective Target Degradation by Folate-Caged PROTACs.

Authors:  Jing Liu; He Chen; Yi Liu; Yudao Shen; Fanye Meng; H Ümit Kaniskan; Jian Jin; Wenyi Wei
Journal:  J Am Chem Soc       Date:  2021-05-10       Impact factor: 16.383

Review 8.  Targeted protein degradation: A promise for undruggable proteins.

Authors:  Kusal T G Samarasinghe; Craig M Crews
Journal:  Cell Chem Biol       Date:  2021-05-17       Impact factor: 9.039

Review 9.  E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points.

Authors:  Aleša Bricelj; Christian Steinebach; Robert Kuchta; Michael Gütschow; Izidor Sosič
Journal:  Front Chem       Date:  2021-07-05       Impact factor: 5.221

Review 10.  Opportunities and Challenges of Small Molecule Induced Targeted Protein Degradation.

Authors:  Ming He; Wenxing Lv; Yu Rao
Journal:  Front Cell Dev Biol       Date:  2021-06-22
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