Yong Zhang 1 , Qiuyan Weng 2 , Jianming Chen 1 , Jinming Han 3 Show Affiliations »
Abstract
OBJECTIVE: Osteosarcoma is considered as one of the most common types of bone tumors, which occurs among adolescents and children. METHODS: Current therapy strategies still have limited effectiveness therefore, the development of new therapies is urgent. Morusin is a compound isolated from Morus australis (Moraceae). Many studies have reported its anti-tumor effect on several tumor types. However, its role in osteosarcoma is still unclear. RESULTS: In this study, we determined that morusin significantly suppresses the proliferation and promotes the apoptosis of osteosarcoma cells. Furthermore, the migration and invasion of osteosarcoma were reduced after exposure to morusin. The deep mechanism was determined to be the inhibition of the PI3K/AKT signaling pathway. CONCLUSION: In conclusion, our study indicates morusin as a potential candidate for osteosarcoma therapy. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
OBJECTIVE: Osteosarcoma is considered as one of the most common types of bone tumors , which occurs among adolescents and children . METHODS: Current therapy strategies still have limited effectiveness therefore, the development of new therapies is urgent. Morusin is a compound isolated from Morus australis (Moraceae). Many studies have reported its anti-tumor effect on several tumor types. However, its role in osteosarcoma is still unclear. RESULTS: In this study, we determined that morusin significantly suppresses the proliferation and promotes the apoptosis of osteosarcoma cells. Furthermore, the migration and invasion of osteosarcoma were reduced after exposure to morusin . The deep mechanism was determined to be the inhibition of the PI3K/AKT signaling pathway. CONCLUSION: In conclusion, our study indicates morusin as a potential candidate for osteosarcoma therapy. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities: Chemical
Disease
Gene
Species
Keywords:
MMPs; Morusin; PI3K/AKT; human osteosarcoma; osteosarcoma; therapy
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Year: 2020
PMID： 32297574 DOI： 10.2174/1389201021666200416093457
Source DB: PubMed Journal: Curr Pharm Biotechnol ISSN： 1389-2010 Impact factor: 2.837