Yuting Wang1,2, Xinke Liu3,4, Henrik Haraldsson3, Chengcheng Zhu3, Megan Ballweber3, Warren Gasper5, Thomas Hatsukami6, David Saloner3. 1. Department of Radiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No. 2006 Xiyuan Avenue, Chengdu, 611731, China. wangyuting_330@163.com. 2. Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. wangyuting_330@163.com. 3. Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. 4. Department of Interventional Neuroradiology, Beijing Neurosurgical Institute and Beijing Tiantan Hospital, Capital Medical University, Beijing, China. 5. Division of Vascular and Endovascular Surgery, University of California, San Francisco, CA, USA. 6. Department of Surgery, University of Washington, Seattle, WA, USA.
Abstract
OBJECTIVES: This study aims to evaluate the reproducibility of measures of plaque morphology in serially acquired black-blood MRI of untreated atherosclerotic femoral arteries. MATERIALS AND METHODS: MR studies was obtained from 42 timepoints, on 12 patients with known femoral artery atherosclerosis. Images with a 3D isotropic FLASH with DANTE-prepared black blood contrast (DASH) at a 3-T scanner were acquired at baseline, within 1 week, and at 1 month. Six of the patients were scanned additionally at 6 months. Inter-scan and inter-observer variations of arterial area/volume measurements were evaluated. RESULTS: Measurement of vessel area, lumen area, wall area and wall volume showed inter-scan intraclass correlation coefficients (ICC) ranging from 0.92 to 0.97 for 3 scans, 0.91-0.97 for 4 scans, and inter-observer ICCs of 0.89-0.96. Among 3 scans, the coefficients of variance (CV) for the vessel area, lumen area, wall area and wall volume were 4.1%, 6.5%, 7.5%, and 4.4%. CVs among 4 scans ranged from 4.4% to 7.9%, and interobserver CVs ranged from 6.1% to 11.8% for the different area/volume measurements. CONCLUSION: DASH MRI is useful for quantifying atherosclerotic vessel area and volume of femoral arteries with low variability among serial repeated scans and between observers.
OBJECTIVES: This study aims to evaluate the reproducibility of measures of plaque morphology in serially acquired black-blood MRI of untreated atherosclerotic femoral arteries. MATERIALS AND METHODS: MR studies was obtained from 42 timepoints, on 12 patients with known femoral artery atherosclerosis. Images with a 3D isotropic FLASH with DANTE-prepared black blood contrast (DASH) at a 3-T scanner were acquired at baseline, within 1 week, and at 1 month. Six of the patients were scanned additionally at 6 months. Inter-scan and inter-observer variations of arterial area/volume measurements were evaluated. RESULTS: Measurement of vessel area, lumen area, wall area and wall volume showed inter-scan intraclass correlation coefficients (ICC) ranging from 0.92 to 0.97 for 3 scans, 0.91-0.97 for 4 scans, and inter-observer ICCs of 0.89-0.96. Among 3 scans, the coefficients of variance (CV) for the vessel area, lumen area, wall area and wall volume were 4.1%, 6.5%, 7.5%, and 4.4%. CVs among 4 scans ranged from 4.4% to 7.9%, and interobserver CVs ranged from 6.1% to 11.8% for the different area/volume measurements. CONCLUSION: DASH MRI is useful for quantifying atherosclerotic vessel area and volume of femoral arteries with low variability among serial repeated scans and between observers.
Entities:
Keywords:
Atherosclerosis; Black blood; Femoral; MR; Reproducibility
Authors: Hamza El Aidi; Venkatesh Mani; Karen B Weinshelbaum; Silvia H Aguiar; Hiroaki Taniguchi; John E Postley; Daniel D Samber; Emil I Cohen; Jessica Stern; Rob J van der Geest; Johan H C Reiber; Mark Woodward; Valentin Fuster; Samuel S Gidding; Zahi A Fayad Journal: Nat Clin Pract Cardiovasc Med Date: 2009-01-27