Flavia Mattioli1, F Bellomi2, C Stampatori2, S Mariotto3, S Ferrari3, S Monaco3, C Mancinelli4, R Capra4. 1. Neuropsychology Unit, ASST Spedali Civili, Via Nikolajewka 13, 25123, Brescia, Italy. flaviacaterina.mattioli@gmail.com. 2. Neuropsychology Unit, ASST Spedali Civili, Via Nikolajewka 13, 25123, Brescia, Italy. 3. Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy. 4. MS Center, ASST Spedali Civili, Brescia, Italy.
Abstract
BACKGROUND: Serum neurofilament light chain (sNfL) may be used as a biological marker of disease progression in multiple sclerosis (MS), although longitudinal studies correlating cognitive deficits to sNfL are limited. OBJECTIVE: To longitudinally investigate the relation between cognitive dysfunction, sNfL and MRI brain volume in a relapsing remitting MS patients. METHODS: 18 MS patients (9 males and 9 females, mean age 45 years, mean education 12.6 years) all prescribed with interferon beta 1a (44 mcg 3 times per week), are longitudinally evaluated by means of annual clinical exam with EDSS, neuropsychological evaluation with Brief repeatable battery (BRB) and Delis Kaplan Executive function test (DKEFS), dosage of sNfL (SIMOA) and MRI. RESULTS: Here are reported the results of 1 year follow-up. A significantly higher sNfL in MS compared to healthy controls and higher sNfL in patients with greater cognitive impairment were found. Cognitive Impairment Index, memory, executive function tests correlated with sNfL. Gray matter volume resulted unchanged at 1-year follow-up; a weak correlation between some tests' score and selective cortical brain areas was found. CONCLUSION: Our longitudinal pilot study confirms that sNfL are related to cognitive abilities, confirming data of other authors from retrospective studies.
BACKGROUND: Serum neurofilament light chain (sNfL) may be used as a biological marker of disease progression in multiple sclerosis (MS), although longitudinal studies correlating cognitive deficits to sNfL are limited. OBJECTIVE: To longitudinally investigate the relation between cognitive dysfunction, sNfL and MRI brain volume in a relapsing remitting MSpatients. METHODS: 18 MSpatients (9 males and 9 females, mean age 45 years, mean education 12.6 years) all prescribed with interferon beta 1a (44 mcg 3 times per week), are longitudinally evaluated by means of annual clinical exam with EDSS, neuropsychological evaluation with Brief repeatable battery (BRB) and Delis Kaplan Executive function test (DKEFS), dosage of sNfL (SIMOA) and MRI. RESULTS: Here are reported the results of 1 year follow-up. A significantly higher sNfL in MS compared to healthy controls and higher sNfL in patients with greater cognitive impairment were found. Cognitive Impairment Index, memory, executive function tests correlated with sNfL. Gray matter volume resulted unchanged at 1-year follow-up; a weak correlation between some tests' score and selective cortical brain areas was found. CONCLUSION: Our longitudinal pilot study confirms that sNfL are related to cognitive abilities, confirming data of other authors from retrospective studies.
Authors: Federica Scaroni; Caterina Visconte; Maria Serpente; Maria Teresa Golia; Martina Gabrielli; Marijn Huiskamp; Hanneke E Hulst; Tiziana Carandini; Milena De Riz; Anna Pietroboni; Emanuela Rotondo; Elio Scarpini; Daniela Galimberti; Charlotte E Teunissen; Maureen van Dam; Brigit A de Jong; Chiara Fenoglio; Claudia Verderio Journal: Cells Date: 2022-05-05 Impact factor: 7.666
Authors: A Dal-Bianco; R Schranzer; G Grabner; M Lanzinger; S Kolbrink; G Pusswald; P Altmann; M Ponleitner; M Weber; B Kornek; K Zebenholzer; C Schmied; T Berger; H Lassmann; S Trattnig; S Hametner; F Leutmezer; P Rommer Journal: Front Neurol Date: 2021-12-21 Impact factor: 4.003