Literature DB >> 32296272

Microarray results as an indicator of sexual abuse.

Vanessa Russell1, Sarah M Nikkel2, Michelle G K Ward3,4.   

Abstract

This case report illustrates the unexpected identification of intrafamilial sexual abuse of a young mother through genetic testing of her child. The child's genome was found to have a relatively common chromosomal condition with congruent clinical manifestations, but the microarray also suggested a close biological relationship between the parents because of a high degree of homozygosity. This prompted a child protection investigation as the mother had been a minor at the time of conception, and intrafamilial sexual abuse was confirmed. Both the intended and unintended results of microarray should be considered with respect to the health and social context of the child and their biological parents. This becomes particularly important for young mothers and raises protection concerns when significant amounts of homozygosity (consanguinity) are detected.
© The Author(s) 2019. Published by Oxford University Press on behalf of the Canadian Paediatric Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Consanguinity; Genetic testing; Homozygosity; Sexual abuse

Year:  2019        PMID: 32296272      PMCID: PMC7147699          DOI: 10.1093/pch/pxz034

Source DB:  PubMed          Journal:  Paediatr Child Health        ISSN: 1205-7088            Impact factor:   2.253


  9 in total

1.  Identification of incestuous parental relationships by SNP-based DNA microarrays.

Authors:  C P Schaaf; D A Scott; J Wiszniewska; A L Beaudet
Journal:  Lancet       Date:  2011-02-12       Impact factor: 79.321

2.  Child abuse and mental disorders in Canada.

Authors:  Tracie O Afifi; Harriet L MacMillan; Michael Boyle; Tamara Taillieu; Kristene Cheung; Jitender Sareen
Journal:  CMAJ       Date:  2014-04-22       Impact factor: 8.262

3.  Institutional protocol to manage consanguinity detected by genetic testing in pregnancy in a minor.

Authors:  Laura P Chen; Anita E Beck; Karen D Tsuchiya; Penny M Chow; Ghayda M Mirzaa; Rebecca T Wiester; Kenneth W Feldman
Journal:  Pediatrics       Date:  2015-03       Impact factor: 7.124

Review 4.  Points to Consider: Ethical, Legal, and Psychosocial Implications of Genetic Testing in Children and Adolescents.

Authors:  Jeffrey R Botkin; John W Belmont; Jonathan S Berg; Benjamin E Berkman; Yvonne Bombard; Ingrid A Holm; Howard P Levy; Kelly E Ormond; Howard M Saal; Nancy B Spinner; Benjamin S Wilfond; Joseph D McInerney
Journal:  Am J Hum Genet       Date:  2015-07-02       Impact factor: 11.025

5.  The perils of SNP microarray testing: uncovering unexpected consanguinity.

Authors:  Beth A Tarini; Laura L Konczal; Aaron J Goldenberg; Edward B Goldman; Shawn E McCandless
Journal:  Pediatr Neurol       Date:  2013-07       Impact factor: 3.372

6.  Currents in contemporary bioethics. Identifying consanguinity through routine genomic analysis: reporting requirements.

Authors:  Amy L McGuire; Melody J Wang; Frank J Probst
Journal:  J Law Med Ethics       Date:  2012       Impact factor: 1.718

7.  American College of Medical Genetics and Genomics: standards and guidelines for documenting suspected consanguinity as an incidental finding of genomic testing.

Authors:  Catherine W Rehder; Karen L David; Betsy Hirsch; Helga V Toriello; Carolyn M Wilson; Hutton M Kearney
Journal:  Genet Med       Date:  2013-01-17       Impact factor: 8.822

8.  Frequent detection of parental consanguinity in children with developmental disorders by a combined CGH and SNP microarray.

Authors:  Yao-Shan Fan; Xiaomei Ouyang; Jinghong Peng; Stephanie Sacharow; Mustafa Tekin; Deborah Barbouth; Olaf Bodamer; Roman Yusupov; Christina Navarrete; Ana H Heller; Sérgio Dj Pena
Journal:  Mol Cytogenet       Date:  2013-09-20       Impact factor: 2.009

9.  Practice guideline: joint CCMG-SOGC recommendations for the use of chromosomal microarray analysis for prenatal diagnosis and assessment of fetal loss in Canada.

Authors:  Christine M Armour; Shelley Danielle Dougan; Jo-Ann Brock; Radha Chari; Bernie N Chodirker; Isabelle DeBie; Jane A Evans; William T Gibson; Elena Kolomietz; Tanya N Nelson; Frédérique Tihy; Mary Ann Thomas; Dimitri J Stavropoulos
Journal:  J Med Genet       Date:  2018-03-01       Impact factor: 6.318

  9 in total

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