Danielle Aprigio1,2, Guaraci Ken Tanaka1,2, Juliana Bittencourt2,3, Mariana Gongora3,4, Silmar Teixeira1,5, Mauricio Cagy6, Henning Budde7,8,9, Marco Orsini10,11, Pedro Ribeiro1,2,12, Bruna Velasques1,2,4. 1. Universidade Federal do Rio de Janeiro, Instituto de Psiquiatria, Laboratório de Neurofisiologia e Neuropsicologia da Atenção, Rio de Janeiro RJ, Brazil. 2. Instituto de Neurociências Aplicadas, Rio de Janeiro RJ, Brazil. 3. Universidade Veiga de Almeida, Rio de Janeiro RJ, Brazil. 4. Universidade Federal do Rio de Janeiro, Instituto de Psiquiatria, Laboratório de Mapeamento Cerebral e Integração Sensoriomotora, Rio de Janeiro RJ, Brazil. 5. Universidade Federal do Piauí, Laboratório de Plasticidade e Mapeamento Cerebral, Parnaíba PI, Brazil. 6. Universidade Federal do Rio de Janeiro, Programa de Engenharia Biomédica, Rio de Janeiro RJ, Brazil. 7. Lithuanian Sports University (LSU), Kaunas, Lithuania. 8. Faculty of Human Sciences, Medical School Hamburg, Hamburg, Germany. 9. Reykjavik University, Sport Science, Reykajvik, Iceland. 10. Universidade de Vassouras, Rio de Janeiro RJ, Brazil. 11. Universidade Iguaçu, Rio de Janeiro RJ, Brazil. 12. Universidade Federal do Rio de Janeiro, Escola de Educação Física e Desporto, Departamento de Biociências, Rio de Janeiro RJ, Brazil.
Abstract
BACKGROUND: Motor Imagery (MI) represents the cognitive component of the movement and recruits dopaminergic systems. OBJECTIVE: To investigate the role of dopaminergic system through the action of methylphenidate and risperidone over beta coherence during execution, action observation and motor imagery. METHODS: Electroencephalography (EEG) data were recorded before and after the substance intake. For statistical analysis, a three-way ANOVA was used to identify changes in beta coherence induced by the group, task and the moment variables. Statistical significance was set at p≤0.007. RESULTS: We found a main effect for group for C3/CZ, and a main effect for task for CZ/C4 pairs of electrodes. Furthermore, significant differences were found in the post-drug administration between groups for C3/CZ pair of electrodes, and between task for C4/CZ pair of electrodes. CONCLUSION: The administration of methylphenidate and risperidone was able to produce electrocortical changes of the cortical central regions, even when featuring antagonistic effects on the dopaminergic pathways. Moreover, the execution task allowed beta-band modulation increase.
BACKGROUND: Motor Imagery (MI) represents the cognitive component of the movement and recruits dopaminergic systems. OBJECTIVE: To investigate the role of dopaminergic system through the action of methylphenidate and risperidone over beta coherence during execution, action observation and motor imagery. METHODS: Electroencephalography (EEG) data were recorded before and after the substance intake. For statistical analysis, a three-way ANOVA was used to identify changes in beta coherence induced by the group, task and the moment variables. Statistical significance was set at p≤0.007. RESULTS: We found a main effect for group for C3/CZ, and a main effect for task for CZ/C4 pairs of electrodes. Furthermore, significant differences were found in the post-drug administration between groups for C3/CZ pair of electrodes, and between task for C4/CZ pair of electrodes. CONCLUSION: The administration of methylphenidate and risperidone was able to produce electrocortical changes of the cortical central regions, even when featuring antagonistic effects on the dopaminergic pathways. Moreover, the execution task allowed beta-band modulation increase.