Marcela Leticia Leal Gonçalves1, Ana Carolina Costa da Mota2, Alessandro Melo Deana3, Lisyanne Araújo de Souza Cavalcante4, Anna Carolina Ratto Tempestini Horliana5, Christiane Pavani6, Lara Jansiski Motta7, Kristianne Porta Santos Fernandes8, Raquel Agnelli Mesquita-Ferrari9, Daniela Fátima Teixeira da Silva10, Pamella de Barros Motta11, Renato Araújo Prates12, Sandra Kalil Bussadori13. 1. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: marcelalleal@hotmail.com. 2. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: ana_cmota@yahoo.com.br. 3. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: amdeana@gmail.com. 4. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: lisyanne.araujo@gmail.com. 5. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: annacrth@gmail.com. 6. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: chrispavani@gmail.com. 7. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: larajmotta@terra.com.br. 8. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: kristianneporta@gmail.com. 9. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: raquel.mesquita@gmail.com. 10. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: dfteixeira@uni9.pro.br. 11. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: pamellabmotta@gmail.com. 12. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: pratesra@gmail.com. 13. Postgraduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University, Vergueiro Street, 235/249 - Liberdade, ZIP 01504-001, São Paulo, SP, Brazil. Electronic address: sandra.skb@gmail.com.
Abstract
BACKGROUND: This study aimed to evaluate the reduction of halitosis when using antimicrobial photodynamic therapy (aPDT) with Bixa orellana extract and blue light-emitting diode (LED). METHODS:Forty-four UNINOVE students or employees with a diagnosis of sulfide (H2S) ≥ 112 ppb in gas chromatography were selected. The patients were randomly divided in groups: Group 1 (n = 15): aPDT with annatto and LED; Group 2 (n = 14): tongue scraping; Group 3 (n = 15): tongue scraping and aPDT. For aPDT, a wasBixa orellana extract used in a concentration of 20 % w/v (Fórmula e Ação®, São Paulo, Brazil) on the tongue for 2 min, associated with a blue-violet LED (Valo Cordless Ultradent® Products, Inc., South Jordan, UT, USA) (395-480 nm). Six points were irradiated on the back of the tongue, at wavelength 395-480 nm for 20 s, energy of 9.6 J and radiant energy of 6.37 J/cm2 per point. The results were compared before, immediately after treatment and 7 days after. The Friedman test was used for the intragroup analysis and the Kruskal Wallis test for the intergroup analysis. RESULTS: In all groups, there was a difference between baseline and the value immediately after the treatment. In Groups 1 and 3, there was no difference between the baseline and the 7 days control. CONCLUSION: There was an immediate reduction of halitosis, but the reduction was not maintained after 7days.
RCT Entities:
BACKGROUND: This study aimed to evaluate the reduction of halitosis when using antimicrobial photodynamic therapy (aPDT) with Bixa orellana extract and blue light-emitting diode (LED). METHODS: Forty-four UNINOVE students or employees with a diagnosis of sulfide (H2S) ≥ 112 ppb in gas chromatography were selected. The patients were randomly divided in groups: Group 1 (n = 15): aPDT with annatto and LED; Group 2 (n = 14): tongue scraping; Group 3 (n = 15): tongue scraping and aPDT. For aPDT, a wasBixa orellana extract used in a concentration of 20 % w/v (Fórmula e Ação®, São Paulo, Brazil) on the tongue for 2 min, associated with a blue-violet LED (Valo Cordless Ultradent® Products, Inc., South Jordan, UT, USA) (395-480 nm). Six points were irradiated on the back of the tongue, at wavelength 395-480 nm for 20 s, energy of 9.6 J and radiant energy of 6.37 J/cm2 per point. The results were compared before, immediately after treatment and 7 days after. The Friedman test was used for the intragroup analysis and the Kruskal Wallis test for the intergroup analysis. RESULTS: In all groups, there was a difference between baseline and the value immediately after the treatment. In Groups 1 and 3, there was no difference between the baseline and the 7 days control. CONCLUSION: There was an immediate reduction of halitosis, but the reduction was not maintained after 7days.