Sang Yoon Kim1, Chang Mo Moon2, Min Ho Kim3, Seong-Eun Kim1, Hye-Kyung Jung1, Ki-Nam Shim1, Sung-Ae Jung1. 1. Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea. 2. Department of Internal Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea; Tissue Injury Defense Research Center, Ewha Womans University, Seoul, Republic of Korea. 3. Ewha Institute of Convergence Medicine, Ewha Womans University Mokdong Hospital, Seoul, Republic of Korea.
Abstract
BACKGROUND AND AIMS: Data are limited regarding the impact of age and sedation on cardiocerebrovascular disease (CCD) adverse events after GI endoscopy. We investigated the incidence of and risk factors for CCD adverse events after diagnostic GI endoscopy and the impact of age and sedation on these unfavorable outcomes. METHODS: In this nationwide population-based study, the incidence of and risk factors for newly diagnosed CCD within 14 days after diagnostic endoscopy were analyzed using Health Insurance Review and Assessment Service data from January to December 2015. RESULTS: Among 1,943,150 subjects, CCD adverse events occurred in approximately 2.23% within 14 days after endoscopy. According to the performance of sedation during endoscopy (60.1% nonsedation vs 39.9% sedation, midazolam alone [96.4%]), the incidence rates of CCD adverse events (per 10,000 persons) were 275.8 versus 302.8 for EGD, 116.9 versus 143.8 for colonoscopy, and 230.4 versus 243.2 for EGD + colonoscopy, respectively. On multivariate analysis, older age (70-99 years) and sedation were independent risk factors for CCD adverse events. Regarding CCD risk stratified by age and sedation, older age had a significant impact on CCD adverse events in individuals who underwent EGD only or EGD + colonoscopy, but sedation did not. However, both older age and sedation had considerable influence on CCD adverse events in individuals who underwent colonoscopy only. Sedation during endoscopy was significantly associated with minor but not major CCD adverse events. CCD adverse events were significantly higher for inpatients. CONCLUSION: CCD adverse events after diagnostic endoscopy were significantly frequent in individuals with older age (70-99 years) and/or sedation during endoscopy. Stratification by age and sedation shows that the impact of these 2 factors on CCD adverse events differs according to endoscopy type.
BACKGROUND AND AIMS: Data are limited regarding the impact of age and sedation on cardiocerebrovascular disease (CCD) adverse events after GI endoscopy. We investigated the incidence of and risk factors for CCD adverse events after diagnostic GI endoscopy and the impact of age and sedation on these unfavorable outcomes. METHODS: In this nationwide population-based study, the incidence of and risk factors for newly diagnosed CCD within 14 days after diagnostic endoscopy were analyzed using Health Insurance Review and Assessment Service data from January to December 2015. RESULTS: Among 1,943,150 subjects, CCD adverse events occurred in approximately 2.23% within 14 days after endoscopy. According to the performance of sedation during endoscopy (60.1% nonsedation vs 39.9% sedation, midazolam alone [96.4%]), the incidence rates of CCD adverse events (per 10,000 persons) were 275.8 versus 302.8 for EGD, 116.9 versus 143.8 for colonoscopy, and 230.4 versus 243.2 for EGD + colonoscopy, respectively. On multivariate analysis, older age (70-99 years) and sedation were independent risk factors for CCD adverse events. Regarding CCD risk stratified by age and sedation, older age had a significant impact on CCD adverse events in individuals who underwent EGD only or EGD + colonoscopy, but sedation did not. However, both older age and sedation had considerable influence on CCD adverse events in individuals who underwent colonoscopy only. Sedation during endoscopy was significantly associated with minor but not major CCD adverse events. CCD adverse events were significantly higher for inpatients. CONCLUSION:CCD adverse events after diagnostic endoscopy were significantly frequent in individuals with older age (70-99 years) and/or sedation during endoscopy. Stratification by age and sedation shows that the impact of these 2 factors on CCD adverse events differs according to endoscopy type.
Authors: Hong Jun Park; Byung-Wook Kim; Jun Kyu Lee; Yehyun Park; Jin Myung Park; Jun Yong Bae; Seung Young Seo; Jae Min Lee; Jee Hyun Lee; Hyung Ku Chon; Jun-Won Chung; Hyun Ho Choi; Myung Ha Kim; Dong Ah Park; Jae Hung Jung; Joo Young Cho Journal: Clin Endosc Date: 2022-02-22
Authors: Hong Jun Park; Byung-Wook Kim; Jun Kyu Lee; Yehyun Park; Jin Myung Park; Jun Yong Bae; Seung Young Seo; Jae Min Lee; Jee Hyun Lee; Hyung Ku Chon; Jun-Won Chung; Hyun Ho Choi; Myung Ha Kim; Dong Ah Park; Jae Hung Jung; Joo Young Cho Journal: Gut Liver Date: 2022-05-15 Impact factor: 4.519
Authors: S N van Munster; E A Nieuwenhuis; B L A M Weusten; L Alvarez Herrero; A Bogte; A Alkhalaf; B E Schenk; E J Schoon; W Curvers; A D Koch; S E M van de Ven; P J F de Jonge; T Tang; W B Nagengast; F T M Peters; J Westerhof; M H M G Houben; Jacques J G H M Bergman; R E Pouw Journal: J Gastrointest Surg Date: 2020-11-02 Impact factor: 3.452