Literature DB >> 32294402

Reducing Stress PERKs up Anti-tumor Immunity.

Marie-Eve Charbonneau1, Mary X D O'Riordan2.   

Abstract

Myeloid-derived suppressor cells (MDSCs) can promote tumor progression. In this issue of Immunity, Mohamed et al. show that the unfolded protein response sensor, PERK, enhances MDSC-mediated immunosuppression through the NRF2 transcription factor, preventing oxidative damage, mitochondrial DNA release, and DNA sensor-STING-dependent type I interferon production.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Year:  2020        PMID： 32294402      PMCID： PMC7271120          DOI： 10.1016/j.immuni.2020.03.012

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  9 in total

Review 1.  Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications.

Authors:  Martina Musella; Gwenola Manic; Ruggero De Maria; Ilio Vitale; Antonella Sistigu
Journal:  Oncoimmunology       Date:  2017-04-05       Impact factor: 8.110

Review 2.  Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer.

Authors:  Juan R Cubillos-Ruiz; Sarah E Bettigole; Laurie H Glimcher
Journal:  Cell       Date:  2017-02-09       Impact factor: 41.582

Review 3.  The Unfolded Protein Response and Cell Fate Control.

Authors:  Claudio Hetz; Feroz R Papa
Journal:  Mol Cell       Date:  2017-11-05       Impact factor: 17.970

Review 4.  Myeloid-Derived Suppressor Cells in the Tumor Microenvironment.

Authors:  Matthew Dysthe; Robin Parihar
Journal:  Adv Exp Med Biol       Date:  2020       Impact factor: 2.622

5.  The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors.

Authors:  Paul T Thevenot; Rosa A Sierra; Patrick L Raber; Amir A Al-Khami; Jimena Trillo-Tinoco; Parisa Zarreii; Augusto C Ochoa; Yan Cui; Luis Del Valle; Paulo C Rodriguez
Journal:  Immunity       Date:  2014-09-18       Impact factor: 31.745

6.  The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling.

Authors:  Eslam Mohamed; Rosa A Sierra; Jimena Trillo-Tinoco; Yu Cao; Patrick Innamarato; Kyle K Payne; Alvaro de Mingo Pulido; Jessica Mandula; Shuzhong Zhang; Paul Thevenot; Subir Biswas; Sarah K Abdalla; Tara Lee Costich; Kay Hänggi; Carmen M Anadon; Elsa R Flores; Eric B Haura; Shikhar Mehrotra; Shari Pilon-Thomas; Brian Ruffell; David H Munn; Juan R Cubillos-Ruiz; Jose R Conejo-Garcia; Paulo C Rodriguez
Journal:  Immunity       Date:  2020-04-14       Impact factor: 31.745

7.  ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis.

Authors:  Juan R Cubillos-Ruiz; Pedro C Silberman; Melanie R Rutkowski; Sahil Chopra; Alfredo Perales-Puchalt; Minkyung Song; Sheng Zhang; Sarah E Bettigole; Divya Gupta; Kevin Holcomb; Lora H Ellenson; Thomas Caputo; Ann-Hwee Lee; Jose R Conejo-Garcia; Laurie H Glimcher
Journal:  Cell       Date:  2015-06-11       Impact factor: 41.582

Review 8.  Nrf2 in cancers: A double-edged sword.

Authors:  Shijia Wu; Hong Lu; Yongheng Bai
Journal:  Cancer Med       Date:  2019-03-30       Impact factor: 4.452

9.  Mitochondrial DNA stress primes the antiviral innate immune response.

Authors:  A Phillip West; William Khoury-Hanold; Matthew Staron; Michal C Tal; Cristiana M Pineda; Sabine M Lang; Megan Bestwick; Brett A Duguay; Nuno Raimundo; Donna A MacDuff; Susan M Kaech; James R Smiley; Robert E Means; Akiko Iwasaki; Gerald S Shadel
Journal:  Nature       Date:  2015-02-02       Impact factor: 49.962
  9 in total
  1 in total

1.  Endoplasmic reticulum stress contributes to cisplatin-induced chronic kidney disease via the PERK-PKCδ pathway.

Authors:  Shaoqun Shu; Hui Wang; Jiefu Zhu; Ying Fu; Juan Cai; Anqun Chen; Chengyuan Tang; Zheng Dong
Journal:  Cell Mol Life Sci       Date:  2022-07-27       Impact factor: 9.207
  1 in total

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