Jung Eun Yoo1, Wooyoung Jang2, Dong Wook Shin3,4, Su-Min Jeong5,6,7, Hee-Won Jung8, Jinyoung Youn9,10, Kyungdo Han11, Bongseong Kim11. 1. Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea. 2. Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea. 3. Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 4. Department of Clinical Research Design & Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea. 5. Department of Family Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea. 6. Department of Family Medicine, Seoul National University Health Service Center, Seoul, Republic of Korea. 7. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 8. Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea. 9. Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 10. Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea. 11. Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
Abstract
BACKGROUND: If mild parkinsonian signs can be a marker for Parkinson's disease (PD) development, an impaired Timed Up and Go test (TUG) should also be a marker for prodromal PD. OBJECTIVES: To investigate whether the Timed Up and Go test is associated with PD. METHODS: We included 1,196,614 participants at 66 years of age who underwent the National Screening Program for Transitional Ages for Koreans between 2009 and 2014. Timed Up and Go test times were classified into <10 and ≥10 seconds. Incidence of PD was defined using claims data. RESULTS: During the median follow-up period of 3.5 years, participants with slow Timed Up and Go test time had significantly increased risk of developing PD compared with those with normal Timed Up and Go test time (adjusted hazard ratio: 1.28; 95% confidence interval: 1.20-1.37). Furthermore, participants with an abnormal Timed Up and Go test result, defined as ≥20 seconds, had a significantly increased risk of PD compared with those with a normal Timed Up and Go test result (adjusted hazard ratio: 2.18; 95% confidence interval: 1.63-2.92). CONCLUSION: An indicator of subtle motor deficits, the Timed Up and Go test could be a prodromal marker for the risk of PD development.
BACKGROUND: If mild parkinsonian signs can be a marker for Parkinson's disease (PD) development, an impaired Timed Up and Go test (TUG) should also be a marker for prodromal PD. OBJECTIVES: To investigate whether the Timed Up and Go test is associated with PD. METHODS: We included 1,196,614 participants at 66 years of age who underwent the National Screening Program for Transitional Ages for Koreans between 2009 and 2014. Timed Up and Go test times were classified into <10 and ≥10 seconds. Incidence of PD was defined using claims data. RESULTS: During the median follow-up period of 3.5 years, participants with slow Timed Up and Go test time had significantly increased risk of developing PD compared with those with normal Timed Up and Go test time (adjusted hazard ratio: 1.28; 95% confidence interval: 1.20-1.37). Furthermore, participants with an abnormal Timed Up and Go test result, defined as ≥20 seconds, had a significantly increased risk of PD compared with those with a normal Timed Up and Go test result (adjusted hazard ratio: 2.18; 95% confidence interval: 1.63-2.92). CONCLUSION: An indicator of subtle motor deficits, the Timed Up and Go test could be a prodromal marker for the risk of PD development.