Bing Lu1,2,3, Yimin Wang1, Pengfei Zhang4, Yang Liu1, Huixun Jia1, Fenghua Wang1,2,3,5,6, Minwen Zhou7,8,9,10, Xiaodong Sun11,12,13,14,15. 1. Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2. Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. 3. National Clinical Research Center for Eye Diseases, Shanghai, China. 4. Department of Ophthalmology, The first affiliated hospital of Wannan Medical College, Wuhu, China. 5. Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. 6. Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, China. 7. Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. zmw8008@163.com. 8. Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. zmw8008@163.com. 9. National Clinical Research Center for Eye Diseases, Shanghai, China. zmw8008@163.com. 10. Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, China. zmw8008@163.com. 11. Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, Shanghai, China. xdsun@sjtu.edu.cn. 12. Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai, China. xdsun@sjtu.edu.cn. 13. National Clinical Research Center for Eye Diseases, Shanghai, China. xdsun@sjtu.edu.cn. 14. Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, China. xdsun@sjtu.edu.cn. 15. Shanghai engineering center for precise diagnosis and treatment of eye diseases, Shanghai, China. xdsun@sjtu.edu.cn.
Abstract
PURPOSE: To describe the distribution of ganglion cell-inner plexiform layer (GCIPL) thickness among Chinese young adults and report whether the decreased GCIPL thickness is associated with myopia. METHODS: In this study, we included Chinese young adults who underwent Cirrus spectral domain-optical coherence tomography (SD-OCT). SD-OCT was used to measure average and minimum GCIPL thickness, and GCIPL thickness at all sectors. Subfoveal choroidal thickness (CT), axial length (AL), and spherical equivalents (SE) were also measured. RESULTS: A total of 348 eyes were included in the analysis. Average GCIPL thickness showed a significant difference between myopes and emmetropes, with 87.89 ± 3.65 μm for emmetropic groups and 82.65 ± 4.96 μm for myopic groups. The GCIPL thickness was significantly thinner in myopia than in emmetropia at all locations (P < 0.05), affirming that myopia was associated with thinner GCIPL thickness (P = 0.001). The mean subfoveal CT also showed a significant difference between myopes and emmetropes, with 330.57 ± 9.43 μm for emmetropic groups and 265.98 ± 4.12 μm for myopic groups. GCIPL (OR 0.863, 95% CI, 0.785-0.949), AL (OR 2.499, 95% CI, 1.532-4.075) and intraocular pressure (IOP) (OR 1.250, 95% CI, 1.086-1.438) revealed significant associations with myopia. When adjusting for AL, IOP, and anterior chamber depth (ACD) in the myopia subgroup, the GCIPL thickness remained positively associated. CONCLUSIONS: In a specific Chinese young population, myopic eyes have measurably less macular GCIPL thickness than normal eyes. Decreasing GCIPL thickness may be associated with the progression of myopia.
PURPOSE: To describe the distribution of ganglion cell-inner plexiform layer (GCIPL) thickness among Chinese young adults and report whether the decreased GCIPL thickness is associated with myopia. METHODS: In this study, we included Chinese young adults who underwent Cirrus spectral domain-optical coherence tomography (SD-OCT). SD-OCT was used to measure average and minimum GCIPL thickness, and GCIPL thickness at all sectors. Subfoveal choroidal thickness (CT), axial length (AL), and spherical equivalents (SE) were also measured. RESULTS: A total of 348 eyes were included in the analysis. Average GCIPL thickness showed a significant difference between myopes and emmetropes, with 87.89 ± 3.65 μm for emmetropic groups and 82.65 ± 4.96 μm for myopic groups. The GCIPL thickness was significantly thinner in myopia than in emmetropia at all locations (P < 0.05), affirming that myopia was associated with thinner GCIPL thickness (P = 0.001). The mean subfoveal CT also showed a significant difference between myopes and emmetropes, with 330.57 ± 9.43 μm for emmetropic groups and 265.98 ± 4.12 μm for myopic groups. GCIPL (OR 0.863, 95% CI, 0.785-0.949), AL (OR 2.499, 95% CI, 1.532-4.075) and intraocular pressure (IOP) (OR 1.250, 95% CI, 1.086-1.438) revealed significant associations with myopia. When adjusting for AL, IOP, and anterior chamber depth (ACD) in the myopia subgroup, the GCIPL thickness remained positively associated. CONCLUSIONS: In a specific Chinese young population, myopic eyes have measurably less macular GCIPL thickness than normal eyes. Decreasing GCIPL thickness may be associated with the progression of myopia.