Literature DB >> 32291236

SPAG5: An Emerging Oncogene.

Ji He1, Andrew R Green2, Yan Li1, Stephen Y T Chan3, Dong-Xu Liu4.   

Abstract

Sperm-associated Antigen 5 (SPAG5) is a mitotic spindle protein. Recent studies have found that it is overexpressed in many human cancers and functions as an oncogene. Here, we summarize the current underlying mechanisms for its oncogenic roles in regulating cellular behaviors of cancer cells and discuss the possibility of targeting SPAG5 for cancer treatment.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  SPAG5; astrin; cancer therapy; gene amplification; oncogene; therapeutic target

Mesh：

Substances：

Year:  2020        PMID： 32291236     DOI： 10.1016/j.trecan.2020.03.006

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  7 in total

Review 1.  An Overview of siRNA Delivery Strategies for Urological Cancers.

Authors:  Nadia Halib; Nicola Pavan; Carlo Trombetta; Barbara Dapas; Rossella Farra; Bruna Scaggiante; Mario Grassi; Gabriele Grassi
Journal:  Pharmaceutics       Date:  2022-03-27       Impact factor: 6.525

2.  Identification of Tissue-Specific Expressed Hub Genes and Potential Drugs in Rheumatoid Arthritis Using Bioinformatics Analysis.

Authors:  Xuewu Xing; Qun Xia; Baoqi Gong; Zhongyang Shen; Yingze Zhang
Journal:  Front Genet       Date:  2022-03-18       Impact factor: 4.599

3.  Downregulation of sperm-associated antigen 5 inhibits melanoma progression by regulating forkhead box protein M1/A disintegrin and metalloproteinase 17/NOTCH1 signaling.

Authors:  Lin Dang; Cuiping Shi; Qianqian Zhang; Peiyu Liao; Yan Wang
Journal:  Bioengineered       Date:  2022-03       Impact factor: 3.269

4.  Hypoxia-inducible factors, mTOR, and astrin constitute an integrative regulatory network in colon cancer cells.

Authors:  Abril Saint-Martin; Marco Antonio Morquecho-León; Maria Cristina Castañeda-Patlán; Martha Robles-Flores
Journal:  Biochem Biophys Rep       Date:  2022-09-08

5.  Curcumin Improves Keratinocyte Proliferation, Inflammation, and Oxidative Stress through Mediating the SPAG5/FOXM1 Axis in an In Vitro Model of Actinic Dermatitis by Ultraviolet.

Authors:  Quan Chen; Yi Tang; Huiyan Deng; Bihua Liang; Huaping Li; Zhenjie Li; Huilan Zhu; Lezi Chen
Journal:  Dis Markers       Date:  2022-09-09       Impact factor: 3.464

6.  MiR-133a-3p attenuates resistance of non-small cell lung cancer cells to gefitinib by targeting SPAG5.

Authors:  Qing Li; Yueming Wang; Jingdong He
Journal:  J Clin Lab Anal       Date:  2021-05-31       Impact factor: 2.352

7.  Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury.

Authors:  Louisa M S Gerhardt; Jing Liu; Kari Koppitch; Pietro E Cippà; Andrew P McMahon
Journal:  Proc Natl Acad Sci U S A       Date:  2021-07-06       Impact factor: 11.205
  7 in total

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