Literature DB >> 3228716

Synaptonemal complex damage as a measure of genotoxicity at meiosis.

J W Allen1, P A Poorman, L C Backer, J B Gibson, B Westbrook-Collins, M J Moses.   

Abstract

Synaptonemal complex aberrations can provide a sensitive measure of chemical-specific alterations to meiotic chromosomes. Mitomycin C, cyclophosphamide, amsacrine, ellipticine, colchicine, vinblastine sulfate, and cis-platin exposures in mice have been shown to cause various patterns of synaptonemal complex structural damage and synaptic irregularity. These effects are suggestive of abnormal homologue pairing/synapsis/recombination effects which, theoretically, could be implicated in mechanisms leading to aneuploidy and other potentially heritable chromosomal disorders.

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Year:  1988        PMID： 3228716     DOI： 10.1007/bf00117776

Source DB:  PubMed          Journal:  Cell Biol Toxicol        ISSN： 0742-2091            Impact factor:   6.691


  12 in total

1.  Synaptonemal complex damage as a measure of chemical mutagen effects on mammalian germ cells.

Authors:  J W Allen; G K DeWeese; J B Gibson; P A Poorman; M J Moses
Journal:  Mutat Res       Date:  1987-01       Impact factor: 2.433

2.  Synaptonemal complex damage induced by clastogenic and anti-mitotic chemicals: implications for non-disjunction and aneuploidy.

Authors:  J W Allen; J B Gibson; P A Poorman; L C Backer; M J Moses
Journal:  Mutat Res       Date:  1988-10       Impact factor: 2.433

3.  Evidence for reduced recombination on the nondisjoined chromosomes 21 in Down syndrome.

Authors:  A C Warren; A Chakravarti; C Wong; S A Slaugenhaupt; S L Halloran; P C Watkins; C Metaxotou; S E Antonarakis
Journal:  Science       Date:  1987-08-07       Impact factor: 47.728

4.  Chromosome aberrations in F1 from irradiated male mice studied by their synaptonemal complexes.

Authors:  E I Kalikinskaya; O L Kolomiets; V A Shevchenko; Y F Bogdanov
Journal:  Mutat Res       Date:  1986-05       Impact factor: 2.433

5.  Differentiation of the synaptonemal complex and the kinetochore in Locusta spermatocytes studied by whole mount electron microscopy.

Authors:  S J Counce; G F Meyer
Journal:  Chromosoma       Date:  1973-11-21       Impact factor: 4.316

6.  Synaptonemal complexes as indicators of induced structural change in chromosomes after irradiation of spermatogonia.

Authors:  A H Cawood; G Breckon
Journal:  Mutat Res       Date:  1983-11       Impact factor: 2.433

7.  Silver staining of synaptonemal complexes in surface spreads for light and electron microscopy.

Authors:  M E Dresser; M J Moses
Journal:  Exp Cell Res       Date:  1979-07       Impact factor: 3.905

8.  Synaptonemal complex analysis of mouse chromosomal rearrangements. III. Cytogenetic observations on two paracentric inversions.

Authors:  P A Poorman; M J Moses; M T Davisson; T H Roderick
Journal:  Chromosoma       Date:  1981       Impact factor: 4.316

9.  Synaptonemal complex karyotyping in spermatocytes of the Chinese hamster (Cricetulus griseus). IV. Light and electron microscopy of synapsis and nucleolar development by silver staining.

Authors:  M E Dresser; M J Moses
Journal:  Chromosoma       Date:  1980       Impact factor: 4.316

10.  Synaptonemal complex karyotyping in spermatocytes of the Chinese hamster (Cricetulus griseus). I. Morphology of the autosomal complement in spread preparations.

Authors:  M J Moses
Journal:  Chromosoma       Date:  1977-03-16       Impact factor: 4.316
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  5 in total

1.  Aneuploidy induced by cyclophosphamide in developing rat testes.

Authors:  A K Saxena; G Singh
Journal:  In Vitro Cell Dev Biol Anim       Date:  1998-01       Impact factor: 2.416

2.  Cisplatin increases meiotic crossing-over in mice.

Authors:  W H Hanneman; M E Legare; S Sweeney; J C Schimenti
Journal:  Proc Natl Acad Sci U S A       Date:  1997-08-05       Impact factor: 11.205

3.  Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I.

Authors:  Nadine K Kolas; Anton Svetlanov; Michelle L Lenzi; Frank P Macaluso; Steven M Lipkin; R Michael Liskay; John Greally; Winfried Edelmann; Paula E Cohen
Journal:  J Cell Biol       Date:  2005-10-31       Impact factor: 10.539

4.  Exposure to low-dose bisphenol A impairs meiosis in the rat seminiferous tubule culture model: a physiotoxicogenomic approach.

Authors:  Sazan Ali; Gérard Steinmetz; Guillaume Montillet; Marie-Hélène Perrard; Anderson Loundou; Philippe Durand; Marie-Roberte Guichaoua; Odette Prat
Journal:  PLoS One       Date:  2014-09-02       Impact factor: 3.240

Review 5.  The various aspects of genetic and epigenetic toxicology: testing methods and clinical applications.

Authors:  Ning Ren; Manar Atyah; Wan-Yong Chen; Chen-Hao Zhou
Journal:  J Transl Med       Date:  2017-05-22       Impact factor: 5.531
  5 in total

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