Reducing Radiation Dose and Contrast Medium Volume With Application of Dual-Energy CT in Children and Young Adults.

OBJECTIVE. The purpose of this study was to assess if dual-source dual-energy CT (DS-DECT) can be used with lower radiation doses and contrast material volumes than single-energy CT (SECT) in children and young adults. MATERIALS AND METHODS. This retrospective study included 85 consecutive children and young adults (age range, 1 month old to 19 years old; 81 male, 70 female) who underwent contrast-enhanced DS-DECT of the chest (n = 41) or the abdomen and pelvis (n = 44) on second- or third-generation dual-source CT scanners (Somatom Flash or Force, Siemens Healthineers) for clinically indicated reasons. We included 66 age-, sex-, body region-, and weight-matched patients who underwent SECT on the same scanner. Patients were scanned with either SECT (with automatic exposure control using both CARE kV [Siemens Healthineers] and CARE Dose 4D [Siemens Healthineers]) or DS-DECT (with CARE Dose 4D). Two pediatric radiologists assessed clinical indications, radiologic findings, image quality, and any study limitations (noise or artifacts). Patient demographics (age, sex, weight), scan parameters (tube voltage, tube current-time product, pitch, section thickness), CT dose descriptors (volume CT dose index, dose-length product, size-specific dose estimate [SSDE]), and contrast material volume were recorded. Descriptive statistics, paired t test, and Cohen kappa test were performed. RESULTS. Mean patient ages and weights ± SD in DS-DECT (10 ± 6 years old, 38 ± 23 kg) and SECT (11 ± 7 years old, 43 ± 29 kg) groups were not significantly different (p > 0.05). Respective SSDEs for chest DS-DECT (4.0 ± 2.1 mGy), chest SECT (6.1 ± 4.4 mGy), abdomen-pelvis DS-DECT (5.0 ± 5.0 mGy), and abdomen-pelvis SECT (8.3 ± 4.0 mGy) were significantly different (p = 0.003-0.005). Contrast material volume for DS-DECT examinations was 19-22% lower compared with the weight- and body region-matched scans obtained with SECT. Image quality of DECT was acceptable in all patients. CONCLUSION. In children and young adults, chest and abdomen-pelvis DS-DECT enables substantial radiation dose and contrast volume reductions compared with weight- and region-matched SECT.