Duc Trong Quach1,2, Nguyet Thi-My Nguyen3, Uyen Pham-Phuong Vo4,5, Ly Thi-Kim Le5, Cong Hong-Minh Vo5, Phat Tan Ho3, Tran Ngoc Nguyen6, Phuong Kim Bo6, Nam Hoai Nguyen7, Khanh Truong Vu7, Manh Van Dang8, Minh Cao Dinh8, Thai Quang Nguyen9, Xung Van Nguyen9, Suong Thi-Ngoc Le10, Chi Pham Tran10. 1. Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Street, District 5, Ho Chi Minh, Vietnam. drquachtd@gmail.com. 2. Department of Gastroenterology, Gia-Dinh People's Hospital, Ho Chi Minh, Vietnam. drquachtd@gmail.com. 3. Department of Gastroenterology, Cho-Ray Hospital, Ho Chi Minh, Vietnam. 4. Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Street, District 5, Ho Chi Minh, Vietnam. 5. Department of Gastroenterology, Gia-Dinh People's Hospital, Ho Chi Minh, Vietnam. 6. Department of Gastroenterology, Can-Tho Central Hospital, Can Tho, Vietnam. 7. Department of Gastroenterology, Bach-Mai Hospital, Ha Noi, Vietnam. 8. Department of Gastroenterology, Dong-Nai General Hospital, Bien Hoa, Vietnam. 9. Department of Gastroenterology, Da-Nang General Hospital, Da Nang, Vietnam. 10. Department of Gastroenterology, Hue Central Hospital, Hue, Vietnam.
Abstract
BACKGROUND/AIMS: The prevalence of acute lower gastrointestinal bleeding (ALGIB) has progressively increased worldwide but there are few studies in Asian populations. This study aimed to develop and validate a scoring system to predict severe ALGIB in Vietnamese. METHODS: Risk factors for severe ALGIB were identified by multiple logistic regression analysis using data from a retrospective cohort of 357 patients admitted to a tertiary hospital. These factors were weighted to develop the severe acute lower gastrointestinal bleeding (SALGIB) score to predict severe ALGIB. The performance of SALGIB was validated in a prospective cohort of 324 patients admitted to 6 other hospitals using area under the receiver operating characteristics curve (AUC) analysis. RESULTS: There were four factors at admission independently associated with severe ALGIB in the derivation cohort: heart rate ≥ 100/min, systolic blood pressure < 100 mmHg, hematocrit < 35%, and platelets ≤ 150 × 103/µL. The SALGIB score determined severe ALGIB with AUC values of 0.91 and 0.86 in the derivation and validation cohorts, respectively. A SALGIB score < 2 associated with low risk of severe ALGIB in both cohorts (3.7% and 1.2%; respectively). CONCLUSIONS: The SALGIB score has good performance in discriminating risk of severe ALGIB in Vietnamese.
BACKGROUND/AIMS: The prevalence of acute lower gastrointestinal bleeding (ALGIB) has progressively increased worldwide but there are few studies in Asian populations. This study aimed to develop and validate a scoring system to predict severe ALGIB in Vietnamese. METHODS: Risk factors for severe ALGIB were identified by multiple logistic regression analysis using data from a retrospective cohort of 357 patients admitted to a tertiary hospital. These factors were weighted to develop the severe acute lower gastrointestinal bleeding (SALGIB) score to predict severe ALGIB. The performance of SALGIB was validated in a prospective cohort of 324 patients admitted to 6 other hospitals using area under the receiver operating characteristics curve (AUC) analysis. RESULTS: There were four factors at admission independently associated with severe ALGIB in the derivation cohort: heart rate ≥ 100/min, systolic blood pressure < 100 mmHg, hematocrit < 35%, and platelets ≤ 150 × 103/µL. The SALGIB score determined severe ALGIB with AUC values of 0.91 and 0.86 in the derivation and validation cohorts, respectively. A SALGIB score < 2 associated with low risk of severe ALGIB in both cohorts (3.7% and 1.2%; respectively). CONCLUSIONS: The SALGIB score has good performance in discriminating risk of severe ALGIB in Vietnamese.
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