| Literature DB >> 32284603 |
Joseph H Lynch1, Yichun Qian2,3, Longyun Guo1,4, Itay Maoz1, Xing-Qi Huang1, Alekzander S Garcia1,5, Gordon Louie6, Marianne E Bowman6, Joseph P Noel6,7, John A Morgan1,8, Natalia Dudareva9,10,11.
Abstract
In plants, phenylalanine biosynthesis occurs via two compartmentally separated pathways. Overexpression of petunia chorismate mutase 2 (PhCM2), which catalyzes the committed step of the cytosolic pathway, increased flux in cytosolic phenylalanine biosynthesis, but paradoxically decreased the overall levels of phenylalanine and phenylalanine-derived volatiles. Concomitantly, the levels of auxins, including indole-3-acetic acid and its precursor indole-3-pyruvic acid, were elevated. Biochemical and genetic analyses revealed the existence of metabolic crosstalk between the cytosolic phenylalanine biosynthesis and tryptophan-dependent auxin biosynthesis mediated by an aminotransferase that uses a cytosolic phenylalanine biosynthetic pathway intermediate, phenylpyruvate, as an amino acceptor for auxin formation.Mesh：
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Year: 2020 PMID： 32284603 DOI： 10.1038/s41589-020-0519-8
Source DB: PubMed Journal: Nat Chem Biol ISSN： 1552-4450 Impact factor: 15.040