Literature DB >> 322836

Results of a randomized clinical trial of preoperative irradiation versus postoperative in treatment of tumors of the hypopharynx.

C Vandenbrouck, H Sancho, R Le Fur, J M Richard, Y Cachin.   

Abstract

Preoperative radiotherapy vs postoperative radiotherapy in the management of patients with primary tumors of the hypopharynx was evaluated by a prospective, randomized clinical trial. A statistically significant difference (p less than 1%) existed in favor of postoperative radiotherapy relative to survival rates, complications, and quality of survival. The postoperative radiotherapy group showed a 56% 5-year survival rate compared to 20% in the preoperative radiotherapy group. An analysis of the results is discussed.

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Year:  1977        PMID： 322836     DOI： 10.1002/1097-0142(197704)39:4<1445::aid-cncr2820390415>3.0.co;2-6

Source DB:  PubMed          Journal:  Cancer        ISSN： 0008-543X            Impact factor:   6.860


  7 in total

Review 1.  Head and neck cancer: an evolving treatment paradigm.

Authors:  David M Cognetti; Randal S Weber; Stephen Y Lai
Journal:  Cancer       Date:  2008-10-01       Impact factor: 6.860

2.  [Complications after surgery of ENT-tumors. A comparison between preoperatively irradiated and nonirradiated patients].

Authors:  K Laniado; K Schumann; T Silber
Journal:  Arch Otorhinolaryngol       Date:  1980

Review 3.  Chemotherapeutic management of head and neck cancer.

Authors:  M Al-Sarraf
Journal:  Cancer Metastasis Rev       Date:  1987       Impact factor: 9.264

4.  A phase I clinical trial of prolonged infusion of hydroxyurea in combination with hyperfractionated, accelerated, external radiation therapy in patients with advanced squamous cell cancer of the head and neck.

Authors:  J J Beitler; R V Smith; H Haynes; C E Silver; A Quish; T Kotz; M Serrano; A Brook; S Wadler
Journal:  Invest New Drugs       Date:  1998       Impact factor: 3.850

5.  Phase III randomized trial of preoperative concurrent chemoradiotherapy versus preoperative radiotherapy for patients with locally advanced head and neck squamous cell carcinoma.

Authors:  Junlin Yi; Xiaodong Huang; Zhengang Xu; Shaoyan Liu; Xiaolei Wang; Xiaohui He; Dehong Luo; Jingwei Luo; Jianping Xiao; Shiping Zhang; Kai Wang; Yuan Qu; Yuan Tang; Weixin Liu; Guozhen Xu; Li Gao; Dian Wang
Journal:  Oncotarget       Date:  2017-07-04

6.  Traditional transcutaneous approaches in head and neck surgery.

Authors:  Ulrich R Goessler
Journal:  GMS Curr Top Otorhinolaryngol Head Neck Surg       Date:  2012-12-20

7.  Systematic review of postoperative therapy for resected squamous cell carcinoma of the head and neck: Executive summary of the American Radium Society appropriate use criteria.

Authors:  Danielle N Margalit; Assuntina G Sacco; Jay S Cooper; John A Ridge; Richard L Bakst; Beth M Beadle; Jonathan J Beitler; Steven S Chang; Allen M Chen; Tom J Galloway; Shlomo A Koyfman; Carol Mita; Jared R Robbins; C Jillian Tsai; Minh T Truong; Sue S Yom; Farzan Siddiqui
Journal:  Head Neck       Date:  2020-10-23       Impact factor: 3.147
  7 in total

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