Kira Trares1,2,3, Xīn Gào2, Laura Perna4, Dan Rujescu5, Hannah Stocker1,2,3, Tobias Möllers1,2,3, Konrad Beyreuther1, Hermann Brenner1,2, Ben Schöttker1,2. 1. Network Aging Research, Heidelberg University, Heidelberg, Germany. 2. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany. 3. Medical Faculty, Heidelberg University, Heidelberg, Germany. 4. Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany. 5. Department of Psychiatry, University of Halle-Wittenberg, Halle (Saale), Germany.
Abstract
INTRODUCTION: Prospective studies on a potential association of 8-iso-prostaglandin F2α (8-iso-PGF2α ) levels, a biomarker of lipid peroxidation, with dementia are limited. METHODS: Multivariate Cox regression models were used to assess potential associations of urinary 8-iso-PGF2α levels with all-cause, Alzheimer's disease (AD), and vascular dementia (VD) incidence in 5853 older adults from a German, population-based cohort. RESULTS: Over 14 years of follow-up, 365 all-cause dementia cases including 127 VD and 109 AD cases were diagnosed. Participants in the top compared to the bottom 8-iso-PGF2α tertile had a 45% increased risk of all-cause dementia incidence (hazard ratio [95% confidence interval]: 1.45 [1.12 to 1.88]). Interaction with the apolipoprotein E (APOE) ԑ4/ԑ4 genotype was detected (P = .02). Furthermore, continuously modeled, logarithmized 8-iso-PGF2α levels were statistically significantly associated with all-cause dementia and AD incidence. DISCUSSION: Oxidative stress may be involved in the pathogenesis of dementia. Individuals with increased 8-iso-PGF2α levels and the APOE ԑ4/ԑ4 genotype showed a considerably increased dementia risk.
INTRODUCTION: Prospective studies on a potential association of 8-iso-prostaglandin F2α (8-iso-PGF2α ) levels, a biomarker of lipid peroxidation, with dementia are limited. METHODS: Multivariate Cox regression models were used to assess potential associations of urinary 8-iso-PGF2α levels with all-cause, Alzheimer's disease (AD), and vascular dementia (VD) incidence in 5853 older adults from a German, population-based cohort. RESULTS: Over 14 years of follow-up, 365 all-cause dementia cases including 127 VD and 109 AD cases were diagnosed. Participants in the top compared to the bottom 8-iso-PGF2α tertile had a 45% increased risk of all-cause dementia incidence (hazard ratio [95% confidence interval]: 1.45 [1.12 to 1.88]). Interaction with the apolipoprotein E (APOE) ԑ4/ԑ4 genotype was detected (P = .02). Furthermore, continuously modeled, logarithmized 8-iso-PGF2α levels were statistically significantly associated with all-cause dementia and AD incidence. DISCUSSION: Oxidative stress may be involved in the pathogenesis of dementia. Individuals with increased 8-iso-PGF2α levels and the APOE ԑ4/ԑ4 genotype showed a considerably increased dementia risk.
Authors: Ya-Li Jin; Lin Xu; Chao-Qiang Jiang; Wei-Sen Zhang; Jing Pan; Feng Zhu; Tong Zhu; Graham Neil Thomas; Tai-Hing Lam Journal: Int J Environ Res Public Health Date: 2022-05-26 Impact factor: 4.614
Authors: Kira Trares; Megha Bhardwaj; Laura Perna; Hannah Stocker; Agnese Petrera; Stefanie M Hauck; Konrad Beyreuther; Hermann Brenner; Ben Schöttker Journal: Alzheimers Res Ther Date: 2022-09-09 Impact factor: 8.823