Yanfei He1, Qiaowen Wang1, Yiping Ye2, Zhaoying Liu3, Hongxiang Sun4. 1. Laboratory of Natural Drug, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China. 2. Institute of Materia Medica, Zhejiang Academy of Medical Sciences, Hangzhou, 310013, China. 3. Laboratory of Natural Drug, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China; Hunan Engineering Research Center of Veterinary Drug, College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan, 410128, China. 4. Laboratory of Natural Drug, College of Animal Sciences, Zhejiang University, Hangzhou, Zhejiang, 310058, China. Electronic address: sunhx@zju.edu.cn.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Albizia (Leguminosae) comprises about 150 species and some species have been used for the treatment of rheumatism, stomachache, cough, diarrhea, and wounds in traditional and local medicine. The aim of the review: This review article documents and critically assesses the current status of the traditional uses, phytochemistry, pharmacology, and toxicology of the Albizia species. MATERIALS AND METHODS: All provided literatures on the Albizia species were searched using the electronic databases (e.g. Web of Science, Elsevier, Springer, PubMed, ACS, CNKI, Google Scholar, and Baidu Scholar), books, and theses with keywords of 'Albizia' and 'Albizzia'. RESULTS: Albizia species have been used for melancholia, insomnia, wounds, fever, abscesses, diabetes, headache, stomachache, diarrhea, cough, rheumatism, snake bite, malaria, and parasitic infection in traditional and local medicine. These plants mainly contain triterpenoid saponins, flavonoids, lignanoids, alkaloids, phenolic glycosides, etc. Albizia species have been demonstrated to possess various pharmacological activities. Among them, the antidiabetic, anti-inflammatory, antifertility, antianxiety, antidepressant, and anti-fever properties are consistent with the traditional and local applications of the Albizia species. CONCLUSIONS: The traditional and local uses of Albizia species have been partially demonstrated by the pharmacological investigation. However, some traditional applications have not been assessed scientifically due to incomplete methodologies and ambiguous findings. Moreover, no clinical evidences support the health benefits of these plants. The systematic and comprehensive preclinical studies and clinical trials are still required to verify the pharmacological activities, clinical efficacy, and safety of Albizia species.
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Albizia (Leguminosae) comprises about 150 species and some species have been used for the treatment of rheumatism, stomachache, cough, diarrhea, and wounds in traditional and local medicine. The aim of the review: This review article documents and critically assesses the current status of the traditional uses, phytochemistry, pharmacology, and toxicology of the Albizia species. MATERIALS AND METHODS: All provided literatures on the Albizia species were searched using the electronic databases (e.g. Web of Science, Elsevier, Springer, PubMed, ACS, CNKI, Google Scholar, and Baidu Scholar), books, and theses with keywords of 'Albizia' and 'Albizzia'. RESULTS: Albizia species have been used for melancholia, insomnia, wounds, fever, abscesses, diabetes, headache, stomachache, diarrhea, cough, rheumatism, snake bite, malaria, and parasitic infection in traditional and local medicine. These plants mainly contain triterpenoid saponins, flavonoids, lignanoids, alkaloids, phenolic glycosides, etc. Albizia species have been demonstrated to possess various pharmacological activities. Among them, the antidiabetic, anti-inflammatory, antifertility, antianxiety, antidepressant, and anti-fever properties are consistent with the traditional and local applications of the Albizia species. CONCLUSIONS: The traditional and local uses of Albizia species have been partially demonstrated by the pharmacological investigation. However, some traditional applications have not been assessed scientifically due to incomplete methodologies and ambiguous findings. Moreover, no clinical evidences support the health benefits of these plants. The systematic and comprehensive preclinical studies and clinical trials are still required to verify the pharmacological activities, clinical efficacy, and safety of Albizia species.