Literature DB >> 32278685

Targeting TGFβ Signalling in Cancer: Toward Context-Specific Strategies.

Rhiannon French1, Yuliang Feng1, Siim Pauklin2.   

Abstract

The transforming growth factor beta (TGFβ) signalling pathway regulates a range of important cellular processes in a context-dependent manner. Recent discoveries have provided important insights into the regulation of the TGFβ pathway and its change from an antitumorigenic to a protumorigenic pathway. These findings may have important implications for cancer stem cell (CSC) functions and therapeutic strategies.
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Smad2/3; TGFβ signalling pathway; cancer stem cells; epithelial-to-mesenchymal transition; gene expression; pancreatic tumorigenesis

Year:  2020        PMID： 32278685     DOI： 10.1016/j.trecan.2020.03.010

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  3 in total

1.  Measurement of Cell Intrinsic TGF-β Activation Mediated by the Integrin αvβ8.

Authors:  Robert Ian Seed; Stephen Lloyd Nishimura
Journal:  Bio Protoc       Date:  2022-04-20

2.  Peripherally-driven myeloid NFkB and IFN/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer.

Authors:  Jenny Sprooten; Ann Vankerckhoven; An Coosemans; Abhishek D Garg; Isaure Vanmeerbeek; Daniel M Borras; Yani Berckmans; Roxanne Wouters; Raquel S Laureano; Thais Baert; Louis Boon; Chiara Landolfo; Antonia Carla Testa; Daniela Fischerova; Caroline Van Holsbeke; Tom Bourne; Valentina Chiappa; Wouter Froyman; Dominique Schols; Patrizia Agostinis; Dirk Timmerman; Sabine Tejpar; Ignace Vergote
Journal:  J Immunother Cancer       Date:  2021-11       Impact factor: 13.751

3.  ZNF507 affects TGF-β signaling via TGFBR1 and MAP3K8 activation in the progression of prostate cancer to an aggressive state.

Authors:  Wookbong Kwon; Seong-Kyoon Choi; Daehwan Kim; Hyeon-Gyeom Kim; Jin-Kyu Park; Jee Eun Han; Gil-Jae Cho; Sungho Yun; Wookyung Yu; Se-Hyeon Han; Yun-Sok Ha; Jun Nyung Lee; Tae Gyun Kwon; Dong-Hyung Cho; Jun-Koo Yi; Myoung Ok Kim; Zae Young Ryoo; Song Park
Journal:  J Exp Clin Cancer Res       Date:  2021-09-18
  3 in total

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