| Literature DB >> 3227800 |
D Maimone1, L M Grimaldi, G Incorpora, R Biondi, V Sofia, G R Mancuso, L Siciliano, M Ruscica, L Pavone.
Abstract
Three patients at Stage II of subacute sclerosing panencephalitis (SSPE) were treated with semipurified alpha-interferon (IFN) using different combinations of intrathecal and intravenous routes: 1 x 10(6) IU of alpha-IFN were given every other day up to a total of 15 x 10(6) IU. Transient improvement of neurological symptoms and electroencephalogram were noted in all 3, while cognitive function slightly improved in 2 of them. Clinical benefits gradually disappeared 2 to 6 months after cessation of IFN. Intrathecal antibody production did not change substantially, but CSF Leu 3a/Leu 2a ratio appeared to increase. No significant side effects were observed, except for a mild meningeal inflammatory reaction after each intrathecal administration of IFN.Entities:
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Year: 1988 PMID： 3227800 DOI： 10.1111/j.1600-0404.1988.tb03639.x
Source DB: PubMed Journal: Acta Neurol Scand ISSN： 0001-6314 Impact factor: 3.209