Literature DB >> 32277935

Noncoding RNAs Controlling Telomere Homeostasis in Senescence and Aging.

Martina Rossi1, Myriam Gorospe2.   

Abstract

Aging is a universal and time-dependent biological decline associated with progressive deterioration of cells, tissues, and organs. Age-related decay can eventually lead to pathology such as cardiovascular and neurodegenerative diseases, cancer, and diabetes. A prominent molecular process underlying aging is the progressive shortening of telomeres, the structures that protect the ends of chromosomes, eventually triggering cellular senescence. Noncoding (nc)RNAs are emerging as major regulators of telomere length homeostasis. In this review, we describe the impact of ncRNAs on telomere function and discuss their implications in senescence and age-related diseases. We discuss emerging therapeutic strategies targeting telomere-regulatory ncRNAs in aging pathology. Published by Elsevier Ltd.

Entities:  

Keywords:  TERC; TERT; genomic instability; long noncoding RNAs; miRNA; telomerase activity

Mesh：

Substances：

Year:  2020        PMID： 32277935      PMCID： PMC7152597          DOI： 10.1016/j.molmed.2020.01.010

Source DB:  PubMed          Journal:  Trends Mol Med        ISSN： 1471-4914            Impact factor:   11.951


  114 in total

1.  Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres.

Authors:  Emilio Cusanelli; Carmina Angelica Perez Romero; Pascal Chartrand
Journal:  Mol Cell       Date:  2013-09-26       Impact factor: 17.970

2.  The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function.

Authors:  Angelika M Burger; Fangping Dai; Christoph M Schultes; Anthony P Reszka; Michael J Moore; John A Double; Stephen Neidle
Journal:  Cancer Res       Date:  2005-02-15       Impact factor: 12.701

3.  Prevalence and characteristics of TERT and TERC mutations in suspected genetic pulmonary fibrosis.

Authors:  Raphael Borie; Laure Tabèze; Gabriel Thabut; Hilario Nunes; Vincent Cottin; Sylvain Marchand-Adam; Grégoire Prevot; Abdellatif Tazi; Jacques Cadranel; Herve Mal; Lidwine Wemeau-Stervinou; Anne Bergeron Lafaurie; Dominique Israel-Biet; Clement Picard; Martine Reynaud Gaubert; Stephane Jouneau; Jean-Marc Naccache; Julie Mankikian; Christelle Ménard; Jean-François Cordier; Dominique Valeyre; Marion Reocreux; Bernard Grandchamp; Patrick Revy; Caroline Kannengiesser; Bruno Crestani
Journal:  Eur Respir J       Date:  2016-11-11       Impact factor: 16.671

4.  Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines.

Authors:  Xueyin Wang; Karen J Goodrich; Anne R Gooding; Haroon Naeem; Stuart Archer; Richard D Paucek; Daniel T Youmans; Thomas R Cech; Chen Davidovich
Journal:  Mol Cell       Date:  2017-03-16       Impact factor: 17.970

5.  MicroRNA-34a regulates cardiac ageing and function.

Authors:  Reinier A Boon; Kazuma Iekushi; Stefanie Lechner; Timon Seeger; Ariane Fischer; Susanne Heydt; David Kaluza; Karine Tréguer; Guillaume Carmona; Angelika Bonauer; Anton J G Horrevoets; Nathalie Didier; Zenawit Girmatsion; Peter Biliczki; Joachim R Ehrlich; Hugo A Katus; Oliver J Müller; Michael Potente; Andreas M Zeiher; Heiko Hermeking; Stefanie Dimmeler
Journal:  Nature       Date:  2013-02-20       Impact factor: 49.962

6.  Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II.

Authors:  Stefan Schoeftner; Maria A Blasco
Journal:  Nat Cell Biol       Date:  2007-12-23       Impact factor: 28.824

Review 7.  Role of Telomeres and Telomerase in Aging and Cancer.

Authors:  Jerry W Shay
Journal:  Cancer Discov       Date:  2016-03-30       Impact factor: 39.397

8.  Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances.

Authors:  Jérôme D Robin; Andrew T Ludlow; Kimberly Batten; Frédérique Magdinier; Guido Stadler; Kathyrin R Wagner; Jerry W Shay; Woodring E Wright
Journal:  Genes Dev       Date:  2014-11-15       Impact factor: 11.361

Review 9.  Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies.

Authors:  Mohammad A Jafri; Shakeel A Ansari; Mohammed H Alqahtani; Jerry W Shay
Journal:  Genome Med       Date:  2016-06-20       Impact factor: 11.117

Review 10.  Telomeres: Implications for Cancer Development.

Authors:  Aina Bernal; Laura Tusell
Journal:  Int J Mol Sci       Date:  2018-01-19       Impact factor: 5.923
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  5 in total

Review 1.  Recent Advances in Epigenetics of Age-Related Kidney Diseases.

Authors:  Feng Liu; Jiefang Chen; Zhenqiong Li; Xianfang Meng
Journal:  Genes (Basel)       Date:  2022-04-29       Impact factor: 4.141

Review 2.  The Role of microRNAs in Organismal and Skin Aging.

Authors:  Marta Gerasymchuk; Viktoriia Cherkasova; Olga Kovalchuk; Igor Kovalchuk
Journal:  Int J Mol Sci       Date:  2020-07-25       Impact factor: 5.923

Review 3.  Non-Coding RNAs Steering the Senescence-Related Progress, Properties, and Application of Mesenchymal Stem Cells.

Authors:  Jingyi Cai; Hexu Qi; Ke Yao; Yang Yao; Dian Jing; Wen Liao; Zhihe Zhao
Journal:  Front Cell Dev Biol       Date:  2021-03-19

4.  Dysregulated non-coding telomerase RNA component and associated exonuclease XRN1 in leucocytes from women developing preeclampsia-possible link to enhanced senescence.

Authors:  Tove Lekva; Marie Cecilie Paasche Roland; Mette E Estensen; Errol R Norwitz; Tamara Tilburgs; Tore Henriksen; Jens Bollerslev; Kjersti R Normann; Per Magnus; Ole Kristoffer Olstad; Pål Aukrust; Thor Ueland
Journal:  Sci Rep       Date:  2021-10-05       Impact factor: 4.379

5.  Identification of LncRNA Prognostic Signature Associated With Genomic Instability in Pancreatic Adenocarcinoma.

Authors:  Jinfeng Zhu; Qian Huang; Xingyu Peng; Chen Luo; Sicheng Liu; Zitao Liu; Xun Wu; Hongliang Luo
Journal:  Front Oncol       Date:  2022-03-29       Impact factor: 5.738
  5 in total

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