| Literature DB >> 32277929 |
Abstract
Factors of metabolic syndrome including hyperinsulinemia and obesity are well known to increase the risk of cancer incidence and progression. In a recent iScience article, Ramos et al. demonstrate a novel tumor-suppressor role of the circadian transcription factor BMAL1 in triple-negative breast cancer (TNBC) specifically under conditions of hyperinsulinemia.Entities:
Keywords: BMAL1; insulin treatment; metabolism; obesity; triple-negative breast cancer; tumor suppressor
Year: 2020 PMID： 32277929 DOI： 10.1016/j.molmed.2020.01.014
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951