| Literature DB >> 32277928 |
Raquel Boque-Sastre1, Sonia Guil2.
Abstract
In a recent iScience paper by Fan et al., the long noncoding (lnc)RNA CISAL is shown to form a DNA-RNA triplex and to directly regulate BRCA1 transcription, thereby increasing cisplatin sensitivity and serving as a treatment efficacy biomarker. This opens promising avenues of research from both mechanistic and translational perspectives.Entities:
Keywords: BRCA1; GABPA; TSCC; chemoresistance; lncRNA CISAL; triplex
Year: 2020 PMID： 32277928 DOI： 10.1016/j.molmed.2020.01.015
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951