Statin-induced autoimmune hepatitis in patients with type 1 diabetes: A report of two cases and literature review.

Statins are widely used medications for the treatment of hypercholesterolemia as well as prevention of cardiovascular disease. We report two cases with type 1 diabetes who developed autoimmune hepatitis after the administration of statin. The first case developed the marked elevation of liver enzymes six months into atorvastatin therapy. The second case developed liver dysfunction eight months after the initiation of rosuvastatin therapy. Liver biopsies in both cases exhibited either portal, interface, and lobular hepatitis or a piece-meal necrosis with lymphocytes and plasma cell infiltration, that were compatible with autoimmune hepatitis. Then both cases were started on prednisolone, to which they responded well. Liver biopsy is to be considered for type 1 diabetic patients if no improvement of liver dysfunction after discontinuation of statins. This article is protected by copyright. All rights reserved.