Literature DB >> 32276929

TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?

Konrad H Stopsack1, Lorelei A Mucci2, Emmanuel S Antonarakis3, Peter S Nelson4, Philip W Kantoff5.   

Abstract

TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections. ©2020 American Association for Cancer Research.

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Year:  2020        PMID： 32276929      PMCID： PMC7437472          DOI： 10.1158/2159-8290.CD-20-0451

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   38.272


  17 in total

1.  Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2.

Authors:  Shutoku Matsuyama; Noriyo Nagata; Kazuya Shirato; Miyuki Kawase; Makoto Takeda; Fumihiro Taguchi
Journal:  J Virol       Date:  2010-10-06       Impact factor: 5.103

2.  Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium.

Authors:  Eva Böttcher; Tatyana Matrosovich; Michaela Beyerle; Hans-Dieter Klenk; Wolfgang Garten; Mikhail Matrosovich
Journal:  J Virol       Date:  2006-10       Impact factor: 5.103

3.  Androgen receptor CAG repeat polymorphism and risk of TMPRSS2:ERG-positive prostate cancer.

Authors:  Sun Yoo; Andreas Pettersson; Kristina M Jordahl; Rosina T Lis; Sara Lindstrom; Allison Meisner; Elizabeth J Nuttall; Edward C Stack; Meir J Stampfer; Peter Kraft; Myles Brown; Massimo Loda; Edward L Giovannucci; Philip W Kantoff; Lorelei A Mucci
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2014-06-12       Impact factor: 4.254

4.  Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.

Authors:  B Lin; C Ferguson; J T White; S Wang; R Vessella; L D True; L Hood; P S Nelson
Journal:  Cancer Res       Date:  1999-09-01       Impact factor: 12.701

5.  Modification of the association between obesity and lethal prostate cancer by TMPRSS2:ERG.

Authors:  Andreas Pettersson; Rosina T Lis; Allison Meisner; Richard Flavin; Edward C Stack; Michelangelo Fiorentino; Stephen Finn; Rebecca E Graff; Kathryn L Penney; Jennifer R Rider; Elizabeth J Nuttall; Neil E Martin; Howard D Sesso; Michael Pollak; Meir J Stampfer; Philip W Kantoff; Edward L Giovannucci; Massimo Loda; Lorelei A Mucci
Journal:  J Natl Cancer Inst       Date:  2013-11-30       Impact factor: 13.506

6.  The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma.

Authors:  J M Lucas; L True; S Hawley; M Matsumura; C Morrissey; R Vessella; P S Nelson
Journal:  J Pathol       Date:  2008-06       Impact factor: 7.996

7.  Association of Prostate Cancer Risk Variants with TMPRSS2:ERG Status: Evidence for Distinct Molecular Subtypes.

Authors:  Kathryn L Penney; Andreas Pettersson; Irene M Shui; Rebecca E Graff; Peter Kraft; Rosina T Lis; Howard D Sesso; Massimo Loda; Lorelei A Mucci
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2016-03-03       Impact factor: 4.254

8.  Androgen receptor and androgen-dependent gene expression in lung.

Authors:  Laura Mikkonen; Päivi Pihlajamaa; Biswajyoti Sahu; Fu-Ping Zhang; Olli A Jänne
Journal:  Mol Cell Endocrinol       Date:  2009-12-24       Impact factor: 4.102

9.  Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.

Authors:  Stephanie Bertram; Adeline Heurich; Hayley Lavender; Stefanie Gierer; Simon Danisch; Paula Perin; Jared M Lucas; Peter S Nelson; Stefan Pöhlmann; Elizabeth J Soilleux
Journal:  PLoS One       Date:  2012-04-30       Impact factor: 3.240

10.  Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.

Authors:  Zhongshan Cheng; Jie Zhou; Kelvin Kai-Wang To; Hin Chu; Cun Li; Dong Wang; Dong Yang; Shufa Zheng; Ke Hao; Yohan Bossé; Ma'en Obeidat; Corry-Anke Brandsma; You-Qiang Song; Yu Chen; Bo-Jian Zheng; Lanjuan Li; Kwok-Yung Yuen
Journal:  J Infect Dis       Date:  2015-04-22       Impact factor: 5.226
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  131 in total

1.  Sex Hormones and Lung Inflammation.

Authors:  Jorge Reyes-García; Luis M Montaño; Abril Carbajal-García; Yong-Xiao Wang
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

2.  Sex and Gender Differences in Lung Disease.

Authors:  Patricia Silveyra; Nathalie Fuentes; Daniel Enrique Rodriguez Bauza
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 3.  COVID-19 and androgen-targeted therapy for prostate cancer patients.

Authors:  Neil A Bhowmick; Jillian Oft; Tanya Dorff; Sumanta Pal; Neeraj Agarwal; Robert A Figlin; Edwin M Posadas; Stephen J Freedland; Jun Gong
Journal:  Endocr Relat Cancer       Date:  2020-09       Impact factor: 5.678

4.  How to Best Protect People With Diabetes From the Impact of SARS-CoV-2: Report of the International COVID-19 and Diabetes Summit.

Authors:  Jennifer Y Zhang; Trisha Shang; David Ahn; Kong Chen; Gerard Coté; Juan Espinoza; Carlos E Mendez; Elias K Spanakis; Bithika Thompson; Amisha Wallia; Lauren E Wisk; David Kerr; David C Klonoff
Journal:  J Diabetes Sci Technol       Date:  2021-01-21

Review 5.  The amount of cytokine-release defines different shades of Sars-Cov2 infection.

Authors:  S Bindoli; M Felicetti; P Sfriso; A Doria
Journal:  Exp Biol Med (Maywood)       Date:  2020-05-28

Review 6.  Serine Protease Inhibitors to Treat Lung Inflammatory Diseases.

Authors:  Chahrazade El Amri
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 7.  The intersection of COVID-19 and cancer: signaling pathways and treatment implications.

Authors:  Zhi Zong; Yujun Wei; Jiang Ren; Long Zhang; Fangfang Zhou
Journal:  Mol Cancer       Date:  2021-05-17       Impact factor: 27.401

Review 8.  Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies.

Authors:  Hai Deng; Ting-Xuan Tang; Deng Chen; Liang-Sheng Tang; Xiang-Ping Yang; Zhao-Hui Tang
Journal:  Pathogens       Date:  2021-05-11

Review 9.  Highlighting COVID-19: What the imaging exams show about the disease.

Authors:  Lorena Sousa de Carvalho; Ronaldo Teixeira da Silva Júnior; Bruna Vieira Silva Oliveira; Yasmin Silva de Miranda; Nara Lúcia Fonseca Rebouças; Matheus Sande Loureiro; Samuel Luca Rocha Pinheiro; Regiane Santos da Silva; Paulo Victor Silva Lima Medrado Correia; Maria José Souza Silva; Sabrina Neves Ribeiro; Filipe Antônio França da Silva; Breno Bittencourt de Brito; Maria Luísa Cordeiro Santos; Rafael Augusto Oliveira Sodré Leal; Márcio Vasconcelos Oliveira; Fabrício Freire de Melo
Journal:  World J Radiol       Date:  2021-05-28

10.  Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation.

Authors:  Qian Tang; Yue Wang; Ling Ou; Jieling Li; Kai Zheng; Hui Zhan; Jiayu Gu; Guibao Zhou; Shouxia Xie; Jianping Zhang; Wei Huang; Shaoxiang Wang; Xiao Wang
Journal:  Int J Biol Sci       Date:  2021-05-10       Impact factor: 6.580
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