Literature DB >> 32276544

Smad4 induces cell death in HO-8910 and SKOV3 ovarian carcinoma cell lines via PI3K-mTOR involvement.

Yushuang Yao1, Zhe Zhang2, Fanmao Kong3, Zhuqing Mao1, Zhaoyuan Niu1, Chuan Li1, Aiping Chen1.   

Abstract

IMPACT STATEMENT: This study investigated the effect and mechanism of Smad4 in ovarian carcinoma (OC) cell viability and demonstrated that Smad4 acted as a tumor suppressor in OC, which may contribute to the understanding of molecular mechanisms underlying OC occurrence and progression. Smad4 expression was decreased in the OC specimens, but Smad4 recovery in the OC cell lines impaired the survival and viability of OC cells by increasing autophagy and apoptosis. Further investigation showed that Smad4 interacted with the P85 subunit of PI3K and caused deactivation of the PI3K/mTOR pathway. Therefore, Smad4 could be considered as a target in cancer therapy due to its regulatory effect in OC carcinogenesis.

Entities:  

Keywords:  Ovarian carcinoma; PI3K; Smad4; apoptosis; autophagy; mTOR

Mesh：

Substances：

Year:  2020        PMID： 32276544      PMCID： PMC7273890          DOI： 10.1177/1535370220916709

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  40 in total

1.  Regulation of autophagy by transforming growth factor-β (TGF-β) signaling.

Authors:  Hiroshi I Suzuki; Kunihiko Kiyono; Kohei Miyazono
Journal:  Autophagy       Date:  2010-07-01       Impact factor: 16.016

Review 2.  PI3K signaling in cancer: beyond AKT.

Authors:  Evan C Lien; Christian C Dibble; Alex Toker
Journal:  Curr Opin Cell Biol       Date:  2017-03-24       Impact factor: 8.382

3.  Expression profiling identifies altered expression of genes that contribute to the inhibition of transforming growth factor-beta signaling in ovarian cancer.

Authors:  Jan S Sunde; Howard Donninger; Kongming Wu; Michael E Johnson; Richard G Pestell; G Scott Rose; Samuel C Mok; John Brady; Tomas Bonome; Michael J Birrer
Journal:  Cancer Res       Date:  2006-09-01       Impact factor: 12.701

4.  Smad4 deletion in blood vessel endothelial cells promotes ovarian cancer metastasis.

Authors:  Jie Yang; Ya Wang; Zhen Zeng; Long Qiao; Liang Zhuang; Qinglei Gao; Ding Ma; Xiaoyuan Huang
Journal:  Int J Oncol       Date:  2017-04-07       Impact factor: 5.650

5.  Mixed ductal-endocrine carcinomas of the pancreas and ductal adenocarcinomas with scattered endocrine cells: characterization of the endocrine cells.

Authors:  N Ohike; A Jürgensen; M Pipeleers-Marichal; G Klöppel
Journal:  Virchows Arch       Date:  2003-02-06       Impact factor: 4.064

6.  Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth.

Authors:  Murali M Yallapu; Diane M Maher; Vasudha Sundram; Maria C Bell; Meena Jaggi; Subhash C Chauhan
Journal:  J Ovarian Res       Date:  2010-04-29       Impact factor: 4.234

7.  DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-β/SMAD4 signaling.

Authors:  D W Chan; W W Y Hui; J J Wang; M M H Yung; L M N Hui; Y Qin; R R Liang; T H Y Leung; D Xu; K K L Chan; K-M Yao; B K Tsang; H Y S Ngan
Journal:  Oncogene       Date:  2016-09-05       Impact factor: 9.867

Review 8.  Ovarian cancer stem cells: still an elusive entity?

Authors:  Michela Lupia; Ugo Cavallaro
Journal:  Mol Cancer       Date:  2017-03-20       Impact factor: 27.401

9.  miR-183 modulated cell proliferation and apoptosis in ovarian cancer through the TGF-β/Smad4 signaling pathway.

Authors:  Junhui Zhou; Caixia Zhang; Bo Zhou; Daqiong Jiang
Journal:  Int J Mol Med       Date:  2019-01-29       Impact factor: 4.101

Review 10.  The role of TGF-β/SMAD4 signaling in cancer.

Authors:  Ming Zhao; Lopa Mishra; Chu-Xia Deng
Journal:  Int J Biol Sci       Date:  2018-01-12       Impact factor: 6.580
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