Sang-Cheol Bae1, Young Ho Lee2. 1. Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea (Republic of). 2. Department of Rheumatology, Korea University Anam Hospital, Korea University College of Medicine, 73, Goryeodae-ro, Seongbuk-gu, 02841, Seoul, Korea (Republic of). lyhcgh@korea.ac.kr.
Abstract
OBJECTIVE: To investigate the association between HLA‑G polymorphisms and systemic lupus erythematosus (SLE) susceptibility as well as the relationship between circulating soluble HLA‑G (sHLA‑G) levels and SLE. METHODS: A meta-analysis was performed to investigate the relationships between HLA‑G 14-bp insertion (I)/deletion (D), +3142 G/C, +3035 T/C, and +3003 C/T polymorphisms and SLE as well as the relationship between sHLA‑G serum/plasma levels in SLE patients and controls. RESULTS: Eleven publications fulfilled our inclusion criteria. Meta-analysis under the dominant model showed an association in the overall group between the II+ID genotype of HLA‑G 14-bp I/D polymorphism and SLE (OR = 1.213, 95%CI = 1.077-1.365, P = 0.001). Ethnicity-specific meta-analysis showed an association between II+ID and SLE in Asians but not in South American and European populations. No correlation was observed using the allele contrast between HLA‑G +3142 G/C polymorphisms and SLE. Contrastingly, +3035 T/C and +3003 C/T meta-analysis showed a significant allelic association between SLE and HLA‑G polymorphisms (OR = 1.378, 95%CI = 1.109-1.713, P = 0.004; OR = 1.834, 95%CI = 1.112-3.022, P = 0.017; respectively). sHLA‑G levels were significantly higher in the SLE group than in the controls (SMD = 0.637, 95%CI = 0.382-0.892, P < 0.001). CONCLUSION: We showed association of HLA‑G 14-bp I/D, +3035 T/C, and +3003 C/T polymorphisms with SLE susceptibility and significantly higher circulating sHLA‑G levels in SLE patients.
OBJECTIVE: To investigate the association between HLA‑G polymorphisms and systemic lupus erythematosus (SLE) susceptibility as well as the relationship between circulating soluble HLA‑G (sHLA‑G) levels and SLE. METHODS: A meta-analysis was performed to investigate the relationships between HLA‑G 14-bp insertion (I)/deletion (D), +3142 G/C, +3035 T/C, and +3003 C/T polymorphisms and SLE as well as the relationship between sHLA‑G serum/plasma levels in SLE patients and controls. RESULTS: Eleven publications fulfilled our inclusion criteria. Meta-analysis under the dominant model showed an association in the overall group between the II+ID genotype of HLA‑G 14-bp I/D polymorphism and SLE (OR = 1.213, 95%CI = 1.077-1.365, P = 0.001). Ethnicity-specific meta-analysis showed an association between II+ID and SLE in Asians but not in South American and European populations. No correlation was observed using the allele contrast between HLA‑G +3142 G/C polymorphisms and SLE. Contrastingly, +3035 T/C and +3003 C/T meta-analysis showed a significant allelic association between SLE and HLA‑G polymorphisms (OR = 1.378, 95%CI = 1.109-1.713, P = 0.004; OR = 1.834, 95%CI = 1.112-3.022, P = 0.017; respectively). sHLA‑G levels were significantly higher in the SLE group than in the controls (SMD = 0.637, 95%CI = 0.382-0.892, P < 0.001). CONCLUSION: We showed association of HLA‑G 14-bp I/D, +3035 T/C, and +3003 C/T polymorphisms with SLE susceptibility and significantly higher circulating sHLA‑G levels in SLE patients.
Authors: Tingting Chen; Jun Lin; Song Jin; Sha Ma; Liang Yu; Kai Huang; Xiaoqin Huang; Jiayou Chu; Zhaoqing Yang Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi Date: 2014-04
Authors: Shrouk A Mohammed; Laila M Al Kady; Ghada S Boghdadi; Ghada A Dawa; Marian A Gerges; Maher A El Shafai Journal: Int J Gen Med Date: 2022-01-18