Rocco De Vitis1,2, Marco Passiatore1, Andrea Perna1, Silvia Careri3, Vitale Cilli4, Giuseppe Taccardo1,2. 1. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy. 2. Università Cattolica del Sacro Cuore, Roma, Italy. 3. Ospedale Pediatrico Bambino Gesù, Roma, Italy. 4. Chirurgie de la main, CHIREC site Delta, Bruxelles, Italy.
Abstract
INTRODUCTION: This investigation is a prospective cohort study examining the use of Clostridium histolyticum collagenase injection (CCH) for the treatment of Dupuytren's disease (DD) with a 7 years follow-up. METHODS: Forty-five monodigital DD patients were injected with CCH on a single joint. Assessment included measurement of residual passive extension deficit (PED), function (using QuickDASH) and patient satisfaction. RESULTS: 86.7% of PIPJ and 65.6% of MPJ had a worsening of PED. Nevertheless, thirty-nine patients (86.7%) concluded their treatment with only one injection, without any further treatment. CONCLUSION: CCH provides a long-term effective solution. Recurrence occurs, especially in PIPJ, with acceptable rates.
INTRODUCTION: This investigation is a prospective cohort study examining the use of Clostridium histolyticum collagenase injection (CCH) for the treatment of Dupuytren's disease (DD) with a 7 years follow-up. METHODS: Forty-five monodigital DD patients were injected with CCH on a single joint. Assessment included measurement of residual passive extension deficit (PED), function (using QuickDASH) and patient satisfaction. RESULTS: 86.7% of PIPJ and 65.6% of MPJ had a worsening of PED. Nevertheless, thirty-nine patients (86.7%) concluded their treatment with only one injection, without any further treatment. CONCLUSION: CCH provides a long-term effective solution. Recurrence occurs, especially in PIPJ, with acceptable rates.
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