| Literature DB >> 322727 |
M A Cousin, D Lando, T Ojasoo, J P Raynaud.
Abstract
The anomeric aminoglycosides, RU 21886 and RU 23468, which both have a 2-deoxystreptamine residue, stabilize 70S ribosomes to similar extents at low magnesium ion concentrations. Only RU 21886, however, has marked antibacterial and bactericidal activity and gives rise to a high level of misreading in cell-free protein synthesizing systems. It would thus appear that the ability to stabilize the association of the two ribosomal subunits does not necessarily lead to errors in translation.Entities:
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Year: 1977 PMID： 322727 DOI： 10.1016/s0300-9084(77)80086-2
Source DB: PubMed Journal: Biochimie ISSN： 0300-9084 Impact factor: 4.079