Literature DB >> 32272435

Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology.

Ming Shi1, Pengfei Zhang2, Setu M Vora2, Hao Wu3.   

Abstract

Higher-order supramolecular complexes-dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein-protein interactions or by dynamic liquid-liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights.
Copyright © 2020 Elsevier Ltd. All rights reserved.

Entities:  

Year:  2020        PMID： 32272435     DOI： 10.1016/j.ceb.2020.03.002

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  8 in total

1.  Bacterial gasdermins reveal an ancient mechanism of cell death.

Authors:  Alex G Johnson; Tanita Wein; Megan L Mayer; Brianna Duncan-Lowey; Erez Yirmiya; Yaara Oppenheimer-Shaanan; Gil Amitai; Rotem Sorek; Philip J Kranzusch
Journal:  Science       Date:  2022-01-13       Impact factor: 63.714

2.  Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.

Authors:  Chen Shen; Runzhi Li; Roberto Negro; Jiewei Cheng; Setu M Vora; Tian-Min Fu; Anmin Wang; Kaixin He; Liudmila Andreeva; Pu Gao; Zhigang Tian; Richard A Flavell; Shu Zhu; Hao Wu
Journal:  Cell       Date:  2021-10-21       Impact factor: 66.850

Review 3.  Mechanics of a molecular mousetrap-nucleation-limited innate immune signaling.

Authors:  Alejandro Rodríguez Gama; Tayla Miller; Randal Halfmann
Journal:  Biophys J       Date:  2021-01-16       Impact factor: 4.033

Review 4.  Inflammasome Signaling: A Novel Paradigm of Hub Platform in Innate Immunity for Cancer Immunology and Immunotherapy.

Authors:  Ying Li; Jiao Lv; Weikai Shi; Jia Feng; Mingxi Liu; Shenao Gan; Hongjin Wu; Weiwei Fan; Ming Shi
Journal:  Front Immunol       Date:  2021-08-05       Impact factor: 7.561

5.  Helical filament structure of the DREP3 CIDE domain reveals a unified mechanism of CIDE-domain assembly.

Authors:  So Yeon Lee; Sunghark Kwon; Hyun Ji Ha; Sung Hoon Lee; Hyun Ho Park
Journal:  Acta Crystallogr D Struct Biol       Date:  2021-11-11       Impact factor: 7.652

Review 6.  TI: NLRP3 Inflammasome-Dependent Pyroptosis in CNS Trauma: A Potential Therapeutic Target.

Authors:  Conghui Zhou; Jinfeng Zheng; Yunpeng Fan; Junsong Wu
Journal:  Front Cell Dev Biol       Date:  2022-02-02

7.  Novel Inflammasome-Based Risk Score for Predicting Survival and Efficacy to Immunotherapy in Early-Stage Non-Small Cell Lung Cancer.

Authors:  Chih-Cheng Tsao; Hsin-Hung Wu; Ying-Fu Wang; Po-Chien Shen; Wen-Ting Wu; Huang-Yun Chen; Yang-Hong Dai
Journal:  Biomedicines       Date:  2022-06-28

Review 8.  Supramolecular organizing centers at the interface of inflammation and neurodegeneration.

Authors:  Petra Sušjan-Leite; Taja Železnik Ramuta; Elvira Boršić; Sara Orehek; Iva Hafner-Bratkovič
Journal:  Front Immunol       Date:  2022-08-01       Impact factor: 8.786
  8 in total

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