Literature DB >> 32272109

Structure-activity relationship of flavonoid bifunctional inhibitors against Zika virus infection.

Min Zou1, Hongmiao Liu2, Jingyan Li2, Xingang Yao2, Yi Chen2, Changwen Ke3, Shuwen Liu4.   

Abstract

Zika virus (ZIKV) infection is a global public health problem due to its rapid spread and the possibility of causing microcephaly. Currently, no specific antivirals against ZIKV are available for treatment. In the present study, several flavonoids (galangin, kaempferide, quercetin, myricetin and EGCG) were found to reduce ZIKV induced plaques and viral RNA copies with negligible cytotoxic effects on host cells. In addition, inhibition of ZIKV propagation by flavonoids showed structure-activity relationship. Our results demonstrate flavonoids as inhibitors of ZIKV entry and NS2B-NS3 protease. Hence, these flavonoids could be used as potential bifunctional drugs for treating ZIKV infections.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Antiviral; Entry inhibitors; Flavonoids; Protease; Zika virus

Mesh：

Substances：

Year:  2020        PMID： 32272109     DOI： 10.1016/j.bcp.2020.113962

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  9 in total

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Review 5.  Natural products as Zika antivirals.

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Review 6.  Antiviral activities of flavonoids.

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Review 7.  Therapeutic Potential of Glycosyl Flavonoids as Anti-Coronaviral Agents.

Authors:  Patrícia I C Godinho; Raquel G Soengas; Vera L M Silva
Journal:  Pharmaceuticals (Basel)       Date:  2021-06-07

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Review 9.  Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2.

Authors:  F Carrouel; L S Gonçalves; M P Conte; G Campus; J Fisher; L Fraticelli; E Gadea-Deschamps; L Ottolenghi; D Bourgeois
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