Literature DB >> 32272077

The Biology of the HIV-1 Latent Reservoir and Implications for Cure Strategies.

Lillian B Cohn1, Nicolas Chomont2, Steven G Deeks3.   

Abstract

Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells. Here, we describe the mechanisms thought to contribute to its persistence during treatment and highlight findings from numerous recent studies describing the importance of cell proliferation in that process. Continued progress elucidating the biology will enhance our ability to develop effective curative interventions.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2020        PMID： 32272077      PMCID： PMC7219958          DOI： 10.1016/j.chom.2020.03.014

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  135 in total

1.  HIV-1 DNA Is Maintained in Antigen-Specific CD4+ T Cell Subsets in Patients on Long-Term Antiretroviral Therapy Regardless of Recurrent Antigen Exposure.

Authors:  William J Hey-Nguyen; Michelle Bailey; Yin Xu; Kazuo Suzuki; David Van Bockel; Robert Finlayson; Andrew Leigh Brown; Andrew Carr; David A Cooper; Anthony D Kelleher; Kersten K Koelsch; John J Zaunders
Journal:  AIDS Res Hum Retroviruses       Date:  2019-01       Impact factor: 2.205

2.  Comprehensive analysis of unique cases with extraordinary control over HIV replication.

Authors:  Daniel Mendoza; Sarah A Johnson; Bennett A Peterson; Ven Natarajan; Maria Salgado; Robin L Dewar; Peter D Burbelo; Nicole A Doria-Rose; Erin H Graf; Jamieson H Greenwald; Jessica N Hodge; William L Thompson; Nancy A Cogliano; Cheryl L Chairez; Catherine A Rehm; Sara Jones; Claire W Hallahan; Joseph A Kovacs; Irini Sereti; Omar Sued; Sheila A Peel; Robert J O'Connell; Una O'Doherty; Tae-Wook Chun; Mark Connors; Stephen A Migueles
Journal:  Blood       Date:  2012-04-05       Impact factor: 22.113

3.  Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape.

Authors:  Ross A Pollack; R Brad Jones; Mihaela Pertea; Katherine M Bruner; Alyssa R Martin; Allison S Thomas; Adam A Capoferri; Subul A Beg; Szu-Han Huang; Sara Karandish; Haiping Hao; Eitan Halper-Stromberg; Patrick C Yong; Colin Kovacs; Erika Benko; Robert F Siliciano; Ya-Chi Ho
Journal:  Cell Host Microbe       Date:  2017-04-12       Impact factor: 21.023

4.  Drastic decrease of the HIV reservoir in a patient treated with nivolumab for lung cancer.

Authors:  A Guihot; A-G Marcelin; M-A Massiani; A Samri; C Soulié; B Autran; J-P Spano
Journal:  Ann Oncol       Date:  2018-02-01       Impact factor: 32.976

5.  Human Immunodeficiency Virus Type 1 Persistence Following Systemic Chemotherapy for Malignancy.

Authors:  Timothy J Henrich; Kristen S Hobbs; Emily Hanhauser; Eileen Scully; Louise E Hogan; Yvonne P Robles; Kaitlyn S Leadabrand; Francisco M Marty; Christine D Palmer; Stephanie Jost; Christian Körner; Jonathan Z Li; Rajesh T Gandhi; Ayad Hamdan; Jeremy Abramson; Ann S LaCasce; Daniel R Kuritzkes
Journal:  J Infect Dis       Date:  2017-07-15       Impact factor: 5.226

6.  Single-cell analysis of HIV-1 transcriptional activity reveals expression of proviruses in expanded clones during ART.

Authors:  Ann Wiegand; Jonathan Spindler; Feiyu F Hong; Wei Shao; Joshua C Cyktor; Anthony R Cillo; Elias K Halvas; John M Coffin; John W Mellors; Mary F Kearney
Journal:  Proc Natl Acad Sci U S A       Date:  2017-04-17       Impact factor: 11.205

7.  CD32 expressing doublets in HIV-infected gut-associated lymphoid tissue are associated with a T follicular helper cell phenotype.

Authors:  John P Thornhill; Matthew Pace; Genevieve E Martin; Jonathan Hoare; Simon Peake; Carolina Herrera; Chan Phetsouphanh; Jodi Meyerowitz; Emily Hopkins; Helen Brown; Polly Dunn; Natalia Olejniczak; Christian Willberg; Paul Klenerman; Rob Goldin; Julie Fox; Sarah Fidler; John Frater
Journal:  Mucosal Immunol       Date:  2019-06-25       Impact factor: 7.313

8.  Microbial translocation is a cause of systemic immune activation in chronic HIV infection.

Authors:  Jason M Brenchley; David A Price; Timothy W Schacker; Tedi E Asher; Guido Silvestri; Srinivas Rao; Zachary Kazzaz; Ethan Bornstein; Olivier Lambotte; Daniel Altmann; Bruce R Blazar; Benigno Rodriguez; Leia Teixeira-Johnson; Alan Landay; Jeffrey N Martin; Frederick M Hecht; Louis J Picker; Michael M Lederman; Steven G Deeks; Daniel C Douek
Journal:  Nat Med       Date:  2006-11-19       Impact factor: 53.440

9.  PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals.

Authors:  Rémi Fromentin; Sandrina DaFonseca; Cecilia T Costiniuk; Mohamed El-Far; Francesco Andrea Procopio; Frederick M Hecht; Rebecca Hoh; Steven G Deeks; Daria J Hazuda; Sharon R Lewin; Jean-Pierre Routy; Rafick-Pierre Sékaly; Nicolas Chomont
Journal:  Nat Commun       Date:  2019-02-18       Impact factor: 14.919

10.  Permanent control of HIV-1 pathogenesis in exceptional elite controllers: a model of spontaneous cure.

Authors:  Concepcion Casado; Cristina Galvez; Maria Pernas; Laura Tarancon-Diez; Carmen Rodriguez; Víctor Sanchez-Merino; Mar Vera; Isabel Olivares; Rebeca De Pablo-Bernal; Alberto Merino-Mansilla; Jorge Del Romero; Ramon Lorenzo-Redondo; Ezequiel Ruiz-Mateos; María Salgado; Javier Martinez-Picado; Cecilio Lopez-Galindez
Journal:  Sci Rep       Date:  2020-02-05       Impact factor: 4.379
View more
  61 in total

1.  Longitudinal Dynamics of Intact HIV Proviral DNA and Outgrowth Virus Frequencies in a Cohort of Individuals Receiving Antiretroviral Therapy.

Authors:  Shane D Falcinelli; Kayla W Kilpatrick; Jenna Read; Ross Murtagh; Brigitte Allard; Simon Ghofrani; Jennifer Kirchherr; Katherine S James; Erin Stuelke; Caroline Baker; JoAnn D Kuruc; Joseph J Eron; Michael G Hudgens; Cynthia L Gay; David M Margolis; Nancie M Archin
Journal:  J Infect Dis       Date:  2021-07-02       Impact factor: 5.226

2.  Antigen-driven clonal selection shapes the persistence of HIV-1-infected CD4+ T cells in vivo.

Authors:  Francesco R Simonetti; Hao Zhang; Garshasb P Soroosh; Jiayi Duan; Kyle Rhodehouse; Alison L Hill; Subul A Beg; Kevin McCormick; Hayley E Raymond; Christopher L Nobles; John K Everett; Kyungyoon J Kwon; Jennifer A White; Jun Lai; Joseph B Margolick; Rebecca Hoh; Steven G Deeks; Frederic D Bushman; Janet D Siliciano; Robert F Siliciano
Journal:  J Clin Invest       Date:  2021-02-01       Impact factor: 14.808

3.  Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy.

Authors:  Adrienne E Swanstrom; Taina T Immonen; Kelli Oswald; Cathi Pyle; James A Thomas; William J Bosche; Lorna Silipino; Michael Hull; Laura Newman; Vicky Coalter; Adam Wiles; Rodney Wiles; Jacob Kiser; David R Morcock; Rebecca Shoemaker; Randy Fast; Matthew W Breed; Joshua Kramer; Duncan Donohue; Tyler Malys; Christine M Fennessey; Charles M Trubey; Claire Deleage; Jacob D Estes; Jeffrey D Lifson; Brandon F Keele; Gregory Q Del Prete
Journal:  J Clin Invest       Date:  2021-03-15       Impact factor: 14.808

4.  Single center, open label dose escalating trial evaluating once weekly oral ixazomib in ART-suppressed, HIV positive adults and effects on HIV reservoir size in vivo.

Authors:  Nathan W Cummins; Jason Baker; Rana Chakraborty; Patrick G Dean; Enrique Garcia-Rivera; Ashton Krogman; Shaji Kumar; Yury V Kuzmichev; Gregory M Laird; Alan Landay; Mathias Lichterfeld; Maryam Mahmood; Jeffrey Martinson; Mark Maynes; Sekar Natesampillai; Vincent Rajkumar; Yelizaveta Rassadkina; Kristen D Ritter; Christina G Rivera; Stacey A Rizza; Krupa Subramanian; Aaron J Tande; Elizabeth R Wonderlich; Jennifer A Whitaker; John Zeuli; Andrew D Badley
Journal:  EClinicalMedicine       Date:  2021-11-29

5.  Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis.

Authors:  Virender Kumar Pal; Ragini Agrawal; Srabanti Rakshit; Pooja Shekar; Diwakar Tumkur Narasimha Murthy; Annapurna Vyakarnam; Amit Singh
Journal:  Elife       Date:  2021-11-18       Impact factor: 8.140

Review 6.  Chronic obstructive pulmonary disease in HIV.

Authors:  Katerina Byanova; Ken M Kunisaki; Joshua Vasquez; Laurence Huang
Journal:  Expert Rev Respir Med       Date:  2020-11-23       Impact factor: 3.772

7.  Phenotypic analysis of the unstimulated in vivo HIV CD4 T cell reservoir.

Authors:  Jason Neidleman; Xiaoyu Luo; Julie Frouard; Guorui Xie; Feng Hsiao; Tongcui Ma; Vincent Morcilla; Ashley Lee; Sushama Telwatte; Reuben Thomas; Whitney Tamaki; Benjamin Wheeler; Rebecca Hoh; Ma Somsouk; Poonam Vohra; Jeffrey Milush; Katherine Sholtis James; Nancie M Archin; Peter W Hunt; Steven G Deeks; Steven A Yukl; Sarah Palmer; Warner C Greene; Nadia R Roan
Journal:  Elife       Date:  2020-09-29       Impact factor: 8.140

8.  CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues.

Authors:  Nicolas Huot; Philippe Rascle; Cyril Planchais; Vanessa Contreras; Caroline Passaes; Roger Le Grand; Anne-Sophie Beignon; Etienne Kornobis; Rachel Legendre; Hugo Varet; Asier Saez-Cirion; Hugo Mouquet; Beatrice Jacquelin; Michaela Müller-Trutwin
Journal:  Front Immunol       Date:  2021-06-16       Impact factor: 7.561

Review 9.  Analytical Treatment Interruption in HIV Trials: Statistical and Study Design Considerations.

Authors:  Lu Zheng; Camlin Tierney; Ronald J Bosch
Journal:  Curr HIV/AIDS Rep       Date:  2021-07-02       Impact factor: 5.495

Review 10.  Antibody Conjugates for Targeted Therapy Against HIV-1 as an Emerging Tool for HIV-1 Cure.

Authors:  Jeffrey C Umotoy; Steven W de Taeye
Journal:  Front Immunol       Date:  2021-07-01       Impact factor: 7.561
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.