Maria F Becerra1, Vivek Venkatramani1,2, Isildinha M Reis3, Nachiketh Soodana-Prakash1, Sanoj Punnen1,2, Mark L Gonzalgo1,2, Shyamal Raolji1, Erik P Castle4, Michael E Woods5, Robert S Svatek6, Alon Z Weizer7, Badrinath R Konety8, Mathew Tollefson4, Tracey L Krupski9, Norm D Smith10, Ahmad Shabsigh11, Daniel A Barocas12, Marcus L Quek13, Atreya Dash14, Dipen J Parekh1,2. 1. Department of Urology, University of Miami Miller School of Medicine, Miami, Florida. 2. Sylvester Comprehensive Cancer Center, University of Miami, Miami, Florida. 3. Division of Biostatistics, Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, Florida. 4. Department of Urology, Mayo Clinic, Phoenix, Arizona. 5. Department of Urology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. 6. Department of Urology, Division of Urologic Oncology, University of Texas Health Science Center at San Antonio, San Antonio, Texas. 7. Department of Urology, University of Michigan, Ann Arbor, Michigan. 8. Department of Urology, University of Minnesota, Minneapolis, Minnesota. 9. Department of Urology, University of Virginia Health Science Center, Charlottesville, Virginia. 10. Department of Urology, University of Chicago, Chicago, Illinois. 11. Department of Urology, Ohio State University, Columbus, Ohio. 12. Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee. 13. Department of Urology, Loyola University Medical Center, Maywood, Illinois. 14. Department of Urology, University of Washington, Seattle, Washington.
Abstract
PURPOSE: We evaluated health related quality of life following robotic and open radical cystectomy as a treatment for bladder cancer. MATERIALS AND METHODS: Using the Randomized Open versus Robotic Cystectomy (RAZOR) trial population we assessed health related quality of life by using the Functional Assessment of Cancer Therapy (FACT)-Vanderbilt Cystectomy Index and the Short Form 8 Health Survey (SF-8) at baseline, 3 and 6 months postoperatively. The primary objective was to assess the impact of surgical approach on health related quality of life. As an exploratory analysis we assessed the impact of urinary diversion type on health related quality of life. RESULTS: Analyses were performed in subsets of the per-protocol population of 302 patients. There was no statistically significant difference between the mean scores by surgical approach at any time point for any FACT-Vanderbilt Cystectomy Index subscale or composite score (p >0.05). The emotional well-being score increased over time in both surgical arms. Patients in the open arm showed significantly better SF-8 sores in the physical and mental summary scores at 6 months compared to baseline (p <0.05). Continent diversion (versus noncontinent) was associated with worse FACT-bladder-cystectomy score at 3 (p <0.01) but not at 6 months, and the SF-8 physical component was better in continent-diversion patients at 6 months (p=0.019). CONCLUSIONS: Our data suggests lack of significant differences in the health related quality of life in robotic and open cystectomies. As robotic procedures become more widespread it is important to discuss this finding during counseling.
RCT Entities:
PURPOSE: We evaluated health related quality of life following robotic and open radical cystectomy as a treatment for bladder cancer. MATERIALS AND METHODS: Using the Randomized Open versus Robotic Cystectomy (RAZOR) trial population we assessed health related quality of life by using the Functional Assessment of Cancer Therapy (FACT)-Vanderbilt Cystectomy Index and the Short Form 8 Health Survey (SF-8) at baseline, 3 and 6 months postoperatively. The primary objective was to assess the impact of surgical approach on health related quality of life. As an exploratory analysis we assessed the impact of urinary diversion type on health related quality of life. RESULTS: Analyses were performed in subsets of the per-protocol population of 302 patients. There was no statistically significant difference between the mean scores by surgical approach at any time point for any FACT-Vanderbilt Cystectomy Index subscale or composite score (p >0.05). The emotional well-being score increased over time in both surgical arms. Patients in the open arm showed significantly better SF-8 sores in the physical and mental summary scores at 6 months compared to baseline (p <0.05). Continent diversion (versus noncontinent) was associated with worse FACT-bladder-cystectomy score at 3 (p <0.01) but not at 6 months, and the SF-8 physical component was better in continent-diversion patients at 6 months (p=0.019). CONCLUSIONS: Our data suggests lack of significant differences in the health related quality of life in robotic and open cystectomies. As robotic procedures become more widespread it is important to discuss this finding during counseling.
Entities:
Keywords:
cystectomy; quality of life; urinary diversion
Authors: Vivek Venkatramani; Isildinha M Reis; Mark L Gonzalgo; Erik P Castle; Michael E Woods; Robert S Svatek; Alon Z Weizer; Badrinath R Konety; Mathew Tollefson; Tracey L Krupski; Norm D Smith; Ahmad Shabsigh; Daniel A Barocas; Marcus L Quek; Atreya Dash; Dipen J Parekh Journal: JAMA Netw Open Date: 2022-02-01
Authors: Frederik Wessels; Maximilian Lenhart; Manuel Neuberger; Julia Mühlbauer; Johannes Huber; Johannes Breyer; Philipp Nuhn; Maurice S Michel; Julian Koenig; Maximilian C Kriegmair Journal: World J Urol Date: 2021-05-08 Impact factor: 4.226