Literature DB >> 32271180

Plasma Lactate as a Marker for Metabolic Health.

Nicholas T Broskey, Kai Zou1, G Lynis Dohm, Joseph A Houmard.   

Abstract

Blood lactate concentrations traditionally have been used as an index of exercise intensity or clinical hyperlactatemia. However, more recent data suggest that fasting plasma lactate can also be indicative of the risk for subsequent metabolic disease. The hypothesis presented is that fasting blood lactate accumulation reflects impaired mitochondrial substrate use, which in turn influences metabolic disease risk.

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Year:  2020        PMID： 32271180      PMCID： PMC7311283          DOI： 10.1249/JES.0000000000000220

Source DB:  PubMed          Journal:  Exerc Sport Sci Rev        ISSN： 0091-6331            Impact factor:   6.642


  47 in total

1.  Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

Authors:  Timothy R Koves; John R Ussher; Robert C Noland; Dorothy Slentz; Merrie Mosedale; Olga Ilkayeva; James Bain; Robert Stevens; Jason R B Dyck; Christopher B Newgard; Gary D Lopaschuk; Deborah M Muoio
Journal:  Cell Metab       Date:  2008-01       Impact factor: 27.287

2.  Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy.

Authors:  G I Shulman; D L Rothman; T Jue; P Stein; R A DeFronzo; R G Shulman
Journal:  N Engl J Med       Date:  1990-01-25       Impact factor: 91.245

3.  Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance.

Authors:  John J Dubé; Paul M Coen; Giovanna DiStefano; Alexander C Chacon; Nicole L Helbling; Marisa E Desimone; Maja Stafanovic-Racic; Kazanna C Hames; Alex A Despines; Frederico G S Toledo; Bret H Goodpaster
Journal:  Am J Physiol Endocrinol Metab       Date:  2014-10-28       Impact factor: 4.310

Review 4.  Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus.

Authors:  Matthijs K C Hesselink; Vera Schrauwen-Hinderling; Patrick Schrauwen
Journal:  Nat Rev Endocrinol       Date:  2016-07-22       Impact factor: 43.330

5.  Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.

Authors:  David E Kelley; Jing He; Elizabeth V Menshikova; Vladimir B Ritov
Journal:  Diabetes       Date:  2002-10       Impact factor: 9.461

6.  Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.

Authors:  Kitt Falk Petersen; Sylvie Dufour; Douglas Befroy; Rina Garcia; Gerald I Shulman
Journal:  N Engl J Med       Date:  2004-02-12       Impact factor: 91.245

7.  High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance.

Authors:  Esther Phielix; Ruth Meex; D Margriet Ouwens; Lauren Sparks; Joris Hoeks; Gert Schaart; Esther Moonen-Kornips; Matthijs K C Hesselink; Patrick Schrauwen
Journal:  Diabetes       Date:  2012-07-10       Impact factor: 9.461

8.  Is there a metabolic program in the skeletal muscle of obese individuals?

Authors:  Joseph A Houmard; Walter J Pories; G Lynis Dohm
Journal:  J Obes       Date:  2011-04-26

9.  Lactate kinetics at the lactate threshold in trained and untrained men.

Authors:  Laurent A Messonnier; Chi-An W Emhoff; Jill A Fattor; Michael A Horning; Thomas J Carlson; George A Brooks
Journal:  J Appl Physiol (1985)       Date:  2013-04-04

10.  Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial.

Authors:  Maria Chondronikola; Faidon Magkos; Jun Yoshino; Adewole L Okunade; Bruce W Patterson; Michael J Muehlbauer; Christopher B Newgard; Samuel Klein
Journal:  Obesity (Silver Spring)       Date:  2018-02-24       Impact factor: 5.002
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  3 in total

1.  The association between lactate and muscle aerobic substrate oxidation: Is lactate an early marker for metabolic disease in healthy subjects?

Authors:  Nicholas T Broskey; Walter J Pories; Terry E Jones; Charles J Tanner; Donghai Zheng; Ronald N Cortright; Zhen W Yang; Nkaujyi Khang; Josh Yang; Joseph A Houmard; G Lynis Dohm
Journal:  Physiol Rep       Date:  2021-02

Review 2.  Metformin: Expanding the Scope of Application-Starting Earlier than Yesterday, Canceling Later.

Authors:  Yulia A Kononova; Nikolai P Likhonosov; Alina Yu Babenko
Journal:  Int J Mol Sci       Date:  2022-02-21       Impact factor: 5.923

3.  Comparison of Dual Beam Dispersive and FTNIR Spectroscopy for Lactate Detection.

Authors:  Nystha Baishya; Mohammad Mamouei; Karthik Budidha; Meha Qassem; Pankaj Vadgama; Panayiotis A Kyriacou
Journal:  Sensors (Basel)       Date:  2021-03-08       Impact factor: 3.576
  3 in total

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