Mélanie Le Berre1,2,3, Nancy Presse1,3,4,5, Mélanie Morin3,4,5,6, Maryse Larouche3,7,8, Lysanne Campeau3,9,10, Yu Xin Hu1,3,6, Isabelle Reid1,3, Chantale Dumoulin1,2,3. 1. Research Center, Institut universitaire de gériatrie de Montréal, Montreal, Canada. 2. School of Rehabilitation, Université de Montréal, Montreal, Canada. 3. School of Rehabilitation, Université de Sherbrooke, Sherbrooke, Canada. 4. Centre de recherche sur le vieillissement, CIUSSS-de-l'Estrie-CHUS, Sherbrooke, Canada. 5. Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, Canada. 6. School of Rehabilitation, McGill University, Montreal, Canada. 7. Research Center, St Mary's Research Centre, Montreal, Canada. 8. Department of Obstetrics & Gynecology, McGill University, Montreal, Canada. 9. Urology Department, Jewish General Hospital, Montreal, Canada. 10. Department of Surgery/Urology, McGill University, Montreal, Canada.
Abstract
AIMS: The purpose of this scoping review was to map out the existing literature on caffeine intake and lower urinary tract symptoms (LUTS) in adults. METHODS: In this scoping review, we searched for all studies available until June 2019 in MEDLINE, Embase, CINAHL, Cochrane Central Register, PsycINFO, LILACS, LiSSa, Web of Science, and Joanna Briggs Institute electronic databases, in addition to a hand search of the bibliographies of all relevant articles and a gray literature search. Both intervention studies on the effects of caffeine reduction in adults with LUTS and observational studies on the association between caffeine intake and LUTS-related outcomes in adults were included and assessed for methodological quality by two independent reviewers. RESULTS: Fourteen intervention and 12 observational studies were included. Overall, there was a decrease in urgency episodes (level of evidence 2, grade of recommendation B) and nocturnal enuresis episodes (4, C) with caffeine reduction. Observational studies reported an unclear association between caffeine intake and LUTS-related outcomes. Most importantly, this present review highlighted high heterogeneity in the studied populations, caffeine measures, and reported outcomes. There was also unknown or high risk of bias in most identified studies. CONCLUSIONS: Caffeine reduction appears to reduce LUTS. Future studies on caffeine reduction interventions should target populations with urgency and urge urinary incontinence, which show the most promising results, and include valid and reliable measures of caffeine intake and LUTS. Finally, future studies should also use reporting guidelines to ensure lower risk of bias.
AIMS: The purpose of this scoping review was to map out the existing literature on caffeine intake and lower urinary tract symptoms (LUTS) in adults. METHODS: In this scoping review, we searched for all studies available until June 2019 in MEDLINE, Embase, CINAHL, Cochrane Central Register, PsycINFO, LILACS, LiSSa, Web of Science, and Joanna Briggs Institute electronic databases, in addition to a hand search of the bibliographies of all relevant articles and a gray literature search. Both intervention studies on the effects of caffeine reduction in adults with LUTS and observational studies on the association between caffeine intake and LUTS-related outcomes in adults were included and assessed for methodological quality by two independent reviewers. RESULTS: Fourteen intervention and 12 observational studies were included. Overall, there was a decrease in urgency episodes (level of evidence 2, grade of recommendation B) and nocturnal enuresis episodes (4, C) with caffeine reduction. Observational studies reported an unclear association between caffeine intake and LUTS-related outcomes. Most importantly, this present review highlighted high heterogeneity in the studied populations, caffeine measures, and reported outcomes. There was also unknown or high risk of bias in most identified studies. CONCLUSIONS:Caffeine reduction appears to reduce LUTS. Future studies on caffeine reduction interventions should target populations with urgency and urge urinary incontinence, which show the most promising results, and include valid and reliable measures of caffeine intake and LUTS. Finally, future studies should also use reporting guidelines to ensure lower risk of bias.
Authors: Faris Abushamma; Narjis Nassar; Sulafa Omar Najjar; Sobhe Mahmoud Hijaze; Amer Koni; Sa'ed H Zyoud; Amir Aghbar; Rifat Hanbali; Hashim Hashim Journal: Int J Gen Med Date: 2021-11-18