Na Wang1, Hong Lv2, Ming Huang3. 1. Department of Otolaryngology Medical School of Facial Sciences, Hubei University of Science and Technology Xianning, China. 2. School of Nursing, Hubei University of Science and Technology Xianning, China. 3. Department of Thyroid and Breast Surgery, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology Xianning, China.
Abstract
BACKGROUND: In the world, there are approximately 160,000 cases of laryngeal cancer newly diagnosed every year and 95% of the cases are squamous cell carcinoma (LSCC). We conduct this study to investigate the influencing factors in LSCC. METHOD: We used cohort of LSCC cases form the Surveillance, Epidemiology, and End Results (SEER) database (1973-2014) to investigate the relationship between gender and survival. We conducted 1:1 propensity matching to mimic randomized controlled trials. Using the matched group, we investigate the effect of gender on cancer-specific survival (CSS) and overall survival (OS). RESULT: In total, 47881 patients were brought into an unmatched cohort and 17985 cases were brought into a matched cohort. Using the matched group, we conducted a survival analysis. The 1-year, 3-year, and 5-year CSS and OS rates were better in female patients and the subgroup analysis showed the same trend. Cox regression analysis showed gender was an independent prognostic indicator for LSCC patients. CONCLUSION: Gender is an independent prognostic indicator for LSCC patients. Male patients are a high-risk population. IJCEP
BACKGROUND: In the world, there are approximately 160,000 cases of laryngeal cancer newly diagnosed every year and 95% of the cases are squamous cell carcinoma (LSCC). We conduct this study to investigate the influencing factors in LSCC. METHOD: We used cohort of LSCC cases form the Surveillance, Epidemiology, and End Results (SEER) database (1973-2014) to investigate the relationship between gender and survival. We conducted 1:1 propensity matching to mimic randomized controlled trials. Using the matched group, we investigate the effect of gender on cancer-specific survival (CSS) and overall survival (OS). RESULT: In total, 47881 patients were brought into an unmatched cohort and 17985 cases were brought into a matched cohort. Using the matched group, we conducted a survival analysis. The 1-year, 3-year, and 5-year CSS and OS rates were better in female patients and the subgroup analysis showed the same trend. Cox regression analysis showed gender was an independent prognostic indicator for LSCC patients. CONCLUSION: Gender is an independent prognostic indicator for LSCC patients. Male patients are a high-risk population. IJCEP
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