Literature DB >> 32269697

Expression of HDAC1 and RBBP4 correlate with clinicopathologic characteristics and prognosis in breast cancer.

Qingqun Guo1, Kai Cheng1, Xiaohong Wang1, Xiaoqiang Li1, Yue Yu1, Yitong Hua1, Zhenlin Yang1.   

Abstract

Retinoblastoma binding protein 4 (RBBP4) plays an important role in transcription, cell cycle, and proliferation. Immunohistochemistry was performed to assess HDAC1 and RBBP4 expression in 240 BC patients. The expression of HDAC1 and RBBP4 in 12 pairs of BC tissues and their normal tissues was determined by western blotting. Kaplan-Meier analysis and Cox's proportional hazards regression were applied to evaluate the prognostic significance of HDAC1 and RBBP4. HDAC1 and RBBP4 expression in BC was significantly higher than that in normal tissues. HDAC1 was positively correlated with RBBP4 in breast cancer. HDAC1 and RBBP4 were negatively correlated with ER and PR in BC, respectively. The patients with high expression of RBBP4 had a worse overall survival time. The expression of RBBP4 was found to be significantly correlated with lymph node metastasis. RBBP4 may play a major role though HDAC1 in the development, metastasis, and prognosis of BC. IJCEP
Copyright © 2020.

Entities:  

Keywords:  HDAC1; RBBP4; breast cancer; prognosis

Year:  2020        PMID： 32269697      PMCID： PMC7137008     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN： 1936-2625


  30 in total

1.  RB: An essential player in adult neurogenesis.

Authors:  Bensun C Fong; Ruth S Slack
Journal:  Neurogenesis (Austin)       Date:  2017-02-07

2.  Chromatin-modifying complex component Nurf55/p55 associates with histones H3 and H4 and polycomb repressive complex 2 subunit Su(z)12 through partially overlapping binding sites.

Authors:  Agnieszka J Nowak; Claudio Alfieri; Christian U Stirnimann; Vladimir Rybin; Florence Baudin; Nga Ly-Hartig; Doris Lindner; Christoph W Müller
Journal:  J Biol Chem       Date:  2011-05-05       Impact factor: 5.157

3.  HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.

Authors:  S Tharkar-Promod; D P Johnson; S E Bennett; E M Dennis; B G Banowsky; S S Jones; J R Shearstone; S N Quayle; C Min; M Jarpe; T Mosbruger; A D Pomicter; R R Miles; W Y Chen; K N Bhalla; P A Zweidler-McKay; D C Shrieve; M W Deininger; M B Chandrasekharan; S Bhaskara
Journal:  Leukemia       Date:  2017-06-05       Impact factor: 11.528

4.  The expression of histone deacetylase HDAC1 correlates with the progression and prognosis of gastrointestinal malignancy.

Authors:  Lin-Lin Cao; Zhihong Yue; Lianhua Liu; Lin Pei; Yue Yin; Li Qin; Jie Zhao; Huixin Liu; Hui Wang; Mei Jia
Journal:  Oncotarget       Date:  2017-06-13

5.  ZEB1 induces ER-α promoter hypermethylation and confers antiestrogen resistance in breast cancer.

Authors:  Jianbo Zhang; Chen Zhou; Huimin Jiang; Lin Liang; Wen Shi; Quansheng Zhang; Peiqing Sun; Rong Xiang; Yue Wang; Shuang Yang
Journal:  Cell Death Dis       Date:  2017-04-06       Impact factor: 8.469

6.  Role of HDAC1 in the progression of gastric cancer and the correlation with lncRNAs.

Authors:  Zhiqiang Yu; Jun Zeng; Hui Liu; Tian Wang; Ziqi Yu; Jianyong Chen
Journal:  Oncol Lett       Date:  2019-01-23       Impact factor: 2.967

7.  Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4.

Authors:  Lixian Ding; Yuying Zhao; Shuwei Dang; Yue Wang; Xinglong Li; Xiaotong Yu; Zhongsheng Li; Jiufeng Wei; Ming Liu; Guodong Li
Journal:  Mol Cancer       Date:  2019-03-28       Impact factor: 27.401

8.  The Nucleosome Remodeling and Deacetylase Complex NuRD Is Built from Preformed Catalytically Active Sub-modules.

Authors:  W Zhang; A Aubert; J M Gomez de Segura; M Karuppasamy; S Basu; A S Murthy; A Diamante; T A Drury; J Balmer; J Cramard; A A Watson; D Lando; S F Lee; M Palayret; S L Kloet; A H Smits; M J Deery; M Vermeulen; B Hendrich; D Klenerman; C Schaffitzel; I Berger; E D Laue
Journal:  J Mol Biol       Date:  2016-04-23       Impact factor: 5.469

9.  Role of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb.

Authors:  Rayan Naser; Renaud Vandenbosch; Saad Omais; Dayana Hayek; Carine Jaafar; Sawsan Al Lafi; Afaf Saliba; Maarouf Baghdadi; Larissa Skaf; Noël Ghanem
Journal:  Sci Rep       Date:  2016-02-05       Impact factor: 4.379

10.  Selective Inhibition of Histone Deacetylases 1/2/6 in Combination with Gemcitabine: A Promising Combination for Pancreatic Cancer Therapy.

Authors:  Richard S Laschanzky; Lisa E Humphrey; Jihyun Ma; Lynette M Smith; Thomas J Enke; Surendra K Shukla; Aneesha Dasgupta; Pankaj K Singh; Gillian M Howell; Michael G Brattain; Quan P Ly; Adrian R Black; Jennifer D Black
Journal:  Cancers (Basel)       Date:  2019-09-07       Impact factor: 6.639
View more
  8 in total

1.  Expression patterns and therapeutic implications of histone deacetylase-1 across carcinomas: a comprehensive molecular docking and MD simulation study.

Authors:  Bader Alshehri
Journal:  Med Oncol       Date:  2022-09-29       Impact factor: 3.738

2.  RBBP4 plays a vital role in the malignant progression of triple-negative breast cancer by regulating epithelial-mesenchymal transition.

Authors:  Zitong Zheng; Xu Yao; Yi Liu
Journal:  Genes Genomics       Date:  2022-05-27       Impact factor: 2.164

3.  High RRM2 expression has poor prognosis in specific types of breast cancer.

Authors:  Shen-Chao Shi; Yi Zhang; Tao Wang
Journal:  PLoS One       Date:  2022-03-15       Impact factor: 3.240

4.  Design, synthesis, molecular modeling, and bioactivity evaluation of 1,10-phenanthroline and prodigiosin (Ps) derivatives and their Copper(I) complexes against mTOR and HDAC enzymes as highly potent and effective new anticancer therapeutic drugs.

Authors:  M Mustafa Cetin; Wenjing Peng; Daniel Unruh; Michael F Mayer; Yehia Mechref; Kemal Yelekci
Journal:  Front Pharmacol       Date:  2022-10-04       Impact factor: 5.988

5.  Establishment, immunological analysis, and drug prediction of a prognostic signature of ovarian cancer related to histone acetylation.

Authors:  Yujie Fang; Jing Zhao; Xu Guo; Yunfeng Dai; Hao Zhang; Fanxin Yin; Xiaoxu Zhang; Chenxi Sun; Zequan Han; Hecheng Wang; Yanshuo Han
Journal:  Front Pharmacol       Date:  2022-09-12       Impact factor: 5.988

Review 6.  Challenging, Accurate and Feasible: CAF-1 as a Tumour Proliferation Marker of Diagnostic and Prognostic Value.

Authors:  Alexandros G Sykaras; Alexandros Pergaris; Stamatios Theocharis
Journal:  Cancers (Basel)       Date:  2021-05-24       Impact factor: 6.639

7.  RBBP4 promotes colon cancer malignant progression via regulating Wnt/β-catenin pathway.

Authors:  Yan-Dong Li; Zhen Lv; Wei-Fang Zhu
Journal:  World J Gastroenterol       Date:  2020-09-21       Impact factor: 5.742

8.  Structure Based Design of Bicyclic Peptide Inhibitors of RbAp48.

Authors:  Peter 't Hart; Pascal Hommen; Anaïs Noisier; Adrian Krzyzanowski; Darijan Schüler; Arthur T Porfetye; Mohammad Akbarzadeh; Ingrid R Vetter; Hélène Adihou; Herbert Waldmann
Journal:  Angew Chem Int Ed Engl       Date:  2020-11-24       Impact factor: 15.336
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.