| Literature DB >> 32264693 |
Chandrashekhara Manithody1, Christine Denton1, Amber Price1, Keith Blomenkamp1, Yogi Patel1, Adam Welu1, Ester Glbert1, Himani Madnawat1, Sonali Jain1, Gustavo A Villalona2, Ajay K Jain1.
Abstract
IMPACT STATEMENT: Short bowel syndrome is associated with significant comorbidities and mortality. This study is important as unlike current systems, it provides a validated piglet model which mirrors anatomical, histological, and serological characteristics observed in human SBS. This model can be used to advance knowledge into mechanistic pathways and therapeutic modalities to improve outcomes for SBS patients. This study is novel in that in addition to significant reduction in the remnant bowel and noted liver disease, we also developed a method to emulate ileocecal valve resection and described gut adaptive responses which has important clinical implications in humans.Entities:
Keywords: Short bowel syndrome; animal model; bowel resection; ileocecal valve resection; intestinal failure; intestinal failure-associated liver disease; piglet model
Mesh：
Year: 2020 PMID： 32264693 PMCID： PMC7357144 DOI： 10.1177/1535370220915881
Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699