Taking advantage of the disadvantage: employing the high aqueous instability of amorphous calcium carbonate to realize burst drug release within cancer cells.

The high aqueous instability of amorphous calcium carbonate (ACC), which will lead to a burst release of its payload, has generally been recognized as the major obstacle for its further application in nanomedicine. Herein, a locking/unlocking strategy was applied to employ the instability of ACC to realize burst drug release within cancer cells.