Tailoring a two-dimensional graphene oxide surface: dual T1 and T2 MRI contrast agent materials.

A generalized strategy for developing a hybrid two-dimensional nanostructured dual T1-T2 MRI contrast agent (CA), by co-loading graphene oxide with both Mn-doped Fe3O4 (T2 agent) and MnO (T1 agent) magnetic nanoparticles, is reported. Typical T1/T2 signal quenching, due to magnetic coupling, was not observed because of the fair T1 CA separation distance from the T2 CA on the graphene oxide. The resultant two-dimensional nanostructured MRI CA complements the existing dual T1-T2 MRI CA libraries.