A generally useful palladium-catalyzed method for the asymmetric allylic amination with a large variety of isatins, sulfonamides, imides, amines, and N-heterocycles is introduced. A single protocol with a readily available catalyst accomplishes this reaction at room temperature with high yields and enantioselectivities often exceeding 90%, which is demonstrated with 31 examples.
A generally useful palladium-catalyzed method for the asymmetric allylic amination with a large variety of n class="Chemical">isatins, sulfonamides, imides, amines, and N-heterocycles is introduced. A single protocol with a readily available catalyst accomplishes this reaction at room temperature with high yields and enantioselectivities often exceeding 90%, which is demonstrated with 31 examples.
Authors: Joseph B Sweeney; Anthony K Ball; Philippa A Lawrence; Mackenzie C Sinclair; Luke J Smith Journal: Angew Chem Int Ed Engl Date: 2018-07-12 Impact factor: 15.336