Stefan Mm Goetz1, Todd Lucas1,2,3,4. 1. Department of Psychology, Wayne State University, 5057 Woodward Ave., Detroit, MI 48202, USA. 2. Division of Public Health, College of Human Medicine, Michigan State University, 200 East 1st Street, Flint, MI 48502, USA. 3. Department of Epidemiology & Biostatistics, College of Human Medicine, Michigan State University, 909 Wilson Road, B636, East Lansing, MI 48824, USA. 4. Institute for Interdisciplinary Salivary Bioscience Research, University of California Irvine, 4201 SBSG., Irvine, CA 92697-7085, USA.
Abstract
Aim: Noninvasive assessments of C-reactive protein (CRP) in stress contexts have seldom been compared. This study evaluated CRP response to acute social stress as measured in saliva and dried blood spot (DBS). Materials & methods: African-Americans (N = 118; mean age = 32 years) participated in a laboratory-based social-evaluative stressor task. Six saliva samples taken before, during and after were assayed for salivary CRP. DBS measurements of CRP were taken alongside saliva at the first and last collection. Results: Salivary and DBS CRP were modestly positively associated with one another at baseline, and only salivary CRP increased in response to the stressor task. Conclusion: Noninvasive measures of CRP reactivity may be only moderately related to one another in stress reactivity contexts.
Aim: Noninvasive assessments of C-reactive protein (CRP) in stress contexts have seldom been compared. This study evaluated CRP response to acute social stress as measured in saliva and dried blood spot (DBS). Materials & methods: African-Americans (N = 118; mean age = 32 years) participated in a laboratory-based social-evaluative stressor task. Six saliva samples taken before, during and after were assayed for salivary CRP. DBS measurements of CRP were taken alongside saliva at the first and last collection. Results: Salivary and DBS CRP were modestly positively associated with one another at baseline, and only salivary CRP increased in response to the stressor task. Conclusion: Noninvasive measures of CRP reactivity may be only moderately related to one another in stress reactivity contexts.
Entities:
Keywords:
C-reactive protein; CRP; dried blood spot; inflammation; saliva; stress reactivity; trier social stress test
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