François Gernier1,2, Florence Joly3,4,5,6, Delphine Klein7, Mariette Mercier8,9,10, Michel Velten7,11, Idlir Licaj3,4,12. 1. Clinical Research Departement, François Baclesse Comprehensive Cancer Center, UNICANCER, 3 av General Harris, Caen, 14076, France. f.gernier@baclesse.unicancer.fr. 2. INSERM, U1086, Caen, France. f.gernier@baclesse.unicancer.fr. 3. Clinical Research Departement, François Baclesse Comprehensive Cancer Center, UNICANCER, 3 av General Harris, Caen, 14076, France. 4. INSERM, U1086, Caen, France. 5. UMR-S1077, Université de Caen Basse-Normandie, Caen, France. 6. Department of Oncology, CHU de Caen, Caen, France. 7. Registre des cancers du Bas-Rhin, Inserm IRFAC UMR-S 1113, Université de Strasbourg, Strasbourg, France. 8. EA3181, University of Franche-Comté, Besançon, France. 9. INSERM UMR 1098, University of Franche-Comte, Besançon, France. 10. French National Quality of Life in Oncology Platform, Besançon, France. 11. Service de Santé Publique, Centre Paul Strauss, Strasbourg, France. 12. Department of Community Medicine, Faculty of Health Sciences, The UiT Arctic University of Norway, Tromsø, Norway.
Abstract
BACKGROUND: While several studies have documented fatigue during and after cancer treatment, long-term cancer survivor fatigue is underreported. In this study, we compare fatigue, quality of life (QoL), and anxiety between relapse-free cancer survivors 15 years after diagnosis and healthy controls. METHODS: Cancer survivors (CS) were randomly selected from three large population-based cancer registries (Bas-Rhin, Calvados, and Doubs, France). Cancer-free controls were randomly selected from electoral lists with stratification on age group, residence area, and gender. All participants completed self-reported fatigue (MFI), QoL (EORTC QLQ-C30), and anxiety (STAI) questionnaires. Univariable and multivariable logistic regression were used to study the association between fatigue and cancer status, in three cancer subgroups: breast cancer (BC), cervical cancer (CC), and colorectal cancer (CRC). RESULTS: Two hundred sixty-three CS and 688 controls (125/275, 45/153, 93/260 CS/controls for BC, CC, and CRC respectively) were included. The mean age was 66 years. In multivariable analyses, CS had higher general and mental fatigue than controls p = 0.04 and p = 0.02, respectively. No difference in QoL was observed between CS and controls. CS were more anxious than controls (p < 0.01). Anxiety was associated with general fatigue (p < 0.0001) and mental fatigue (p < 0.0001). CONCLUSION: Fifteen years after diagnosis, cancer survivors reported more general and mental fatigue compared with controls. Our results reinforce guidelines, identifying fatigue as a persistent symptom.
BACKGROUND: While several studies have documented fatigue during and after cancer treatment, long-term cancer survivor fatigue is underreported. In this study, we compare fatigue, quality of life (QoL), and anxiety between relapse-free cancer survivors 15 years after diagnosis and healthy controls. METHODS:Cancer survivors (CS) were randomly selected from three large population-based cancer registries (Bas-Rhin, Calvados, and Doubs, France). Cancer-free controls were randomly selected from electoral lists with stratification on age group, residence area, and gender. All participants completed self-reported fatigue (MFI), QoL (EORTC QLQ-C30), and anxiety (STAI) questionnaires. Univariable and multivariable logistic regression were used to study the association between fatigue and cancer status, in three cancer subgroups: breast cancer (BC), cervical cancer (CC), and colorectal cancer (CRC). RESULTS: Two hundred sixty-three CS and 688 controls (125/275, 45/153, 93/260 CS/controls for BC, CC, and CRC respectively) were included. The mean age was 66 years. In multivariable analyses, CS had higher general and mental fatigue than controls p = 0.04 and p = 0.02, respectively. No difference in QoL was observed between CS and controls. CS were more anxious than controls (p < 0.01). Anxiety was associated with general fatigue (p < 0.0001) and mental fatigue (p < 0.0001). CONCLUSION: Fifteen years after diagnosis, cancer survivors reported more general and mental fatigue compared with controls. Our results reinforce guidelines, identifying fatigue as a persistent symptom.
Entities:
Keywords:
Breast cancer; Cervical cancer; Colorectal cancer; Fatigue; Long-term survivors; Population-based study
Authors: Edvard Abel; Ewa Silander; Fredrik Nordström; Caroline Olsson; N Patrik Brodin; Jan Nyman; Thomas Björk-Eriksson; Eva Hammerlid Journal: Adv Radiat Oncol Date: 2022-04-08
Authors: Daphne H M Jacobs; Ramona K Charaghvandi; Nanda Horeweg; John H Maduro; Gabrielle Speijer; Ellen M A Roeloffzen; Mirjam Mast; Enja Bantema-Joppe; Anna L Petoukhova; Desirée H J G van den Bongard; Peter Koper; Anne P G Crijns; Corrie A M Marijnen; Helena M Verkooijen Journal: Breast Cancer Res Treat Date: 2021-07-03 Impact factor: 4.872