Literature DB >> 32253217

Efficacy of Bedaquiline, Alone or in Combination with Imipenem, against Mycobacterium abscessus in C3HeB/FeJ Mice.

Vincent Le Moigne1, Clément Raynaud2, Flavie Moreau3, Christian Dupont2, Jérôme Nigou3, Olivier Neyrolles3, Laurent Kremer2,4, Jean-Louis Herrmann5,6.   

Abstract

Mycobacterium abscessus lung infections remain difficult to treat. Recent studies have recognized the power of new combinations of antibiotics, such as bedaquiline and imipenem, although in vitro data have questioned this combination. We report that the efficacy of bedaquiline-imipenem combination treatment relies essentially on the activity of bedaquiline in a C3HeB/FeJ mice model of infection with a rough variant of M. abscessus The addition of imipenem contributed to clearing the infection in the spleen.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  C3HeB/FeJ mice; Mycobacterium abscessus; bedaquiline; cystic fibrosis; imipenem

Mesh：

Substances：

Year:  2020        PMID： 32253217      PMCID： PMC7269509          DOI： 10.1128/AAC.00114-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  29 in total

1.  Ipr1 gene mediates innate immunity to tuberculosis.

Authors:  Hui Pan; Bo-Shiun Yan; Mauricio Rojas; Yuriy V Shebzukhov; Hongwei Zhou; Lester Kobzik; Darren E Higgins; Mark J Daly; Barry R Bloom; Igor Kramnik
Journal:  Nature       Date:  2005-04-07       Impact factor: 49.962

2.  In Vitro and Intracellular Activity of Imipenem Combined with Tedizolid, Rifabutin, and Avibactam against Mycobacterium abscessus.

Authors:  Eva Le Run; Michel Arthur; Jean-Luc Mainardi
Journal:  Antimicrob Agents Chemother       Date:  2019-03-27       Impact factor: 5.191

3.  Bedaquiline Inhibits the ATP Synthase in Mycobacterium abscessus and Is Effective in Infected Zebrafish.

Authors:  Christian Dupont; Albertus Viljoen; Sangeeta Thomas; Françoise Roquet-Banères; Jean-Louis Herrmann; Kevin Pethe; Laurent Kremer
Journal:  Antimicrob Agents Chemother       Date:  2017-10-24       Impact factor: 5.191

4.  Inhibition of the β-Lactamase BlaMab by Avibactam Improves the In Vitro and In Vivo Efficacy of Imipenem against Mycobacterium abscessus.

Authors:  Anne-Laure Lefebvre; Vincent Le Moigne; Audrey Bernut; Carole Veckerlé; Fabrice Compain; Jean-Louis Herrmann; Laurent Kremer; Michel Arthur; Jean-Luc Mainardi
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

5.  In vivo evaluation of antibiotic activity against Mycobacterium abscessus.

Authors:  Isabelle Lerat; Emmanuelle Cambau; Romain Roth Dit Bettoni; Jean-Louis Gaillard; Vincent Jarlier; Chantal Truffot; Nicolas Veziris
Journal:  J Infect Dis       Date:  2013-11-18       Impact factor: 5.226

6.  Bacterial phospholipases C as vaccine candidate antigens against cystic fibrosis respiratory pathogens: the Mycobacterium abscessus model.

Authors:  Vincent Le Moigne; Martin Rottman; Céline Goulard; Benoît Barteau; Isabelle Poncin; Nathalie Soismier; Stéphane Canaan; Bruno Pitard; Jean-Louis Gaillard; Jean-Louis Herrmann
Journal:  Vaccine       Date:  2015-03-21       Impact factor: 3.641

7.  A bedaquiline/clofazimine combination regimen might add activity to the treatment of clinically relevant non-tuberculous mycobacteria.

Authors:  Mike Marvin Ruth; Jasper J N Sangen; Karlijn Remmers; Lian J Pennings; Elin Svensson; Rob E Aarnoutse; Sanne M H Zweijpfenning; Wouter Hoefsloot; Saskia Kuipers; Cecile Magis-Escurra; Heiman F L Wertheim; Jakko van Ingen
Journal:  J Antimicrob Chemother       Date:  2019-04-01       Impact factor: 5.790

8.  Susceptibility of Mycobacterium abscessus to antimycobacterial drugs in preclinical models.

Authors:  Andrés Obregón-Henao; Kimberly A Arnett; Marcela Henao-Tamayo; Lisa Massoudi; Elizabeth Creissen; Koen Andries; Anne J Lenaerts; Diane J Ordway
Journal:  Antimicrob Agents Chemother       Date:  2015-08-24       Impact factor: 5.191

9.  Animal model of Mycobacterium abscessus lung infection.

Authors:  Diane Ordway; Marcela Henao-Tamayo; Erin Smith; Crystal Shanley; Marisa Harton; Jolynn Troudt; Xiyuan Bai; Randall J Basaraba; Ian M Orme; Edward D Chan
Journal:  J Leukoc Biol       Date:  2008-02-29       Impact factor: 4.962

10.  Tracking the immunopathological response to Pseudomonas aeruginosa during respiratory infections.

Authors:  Cristina Cigana; Nicola Ivan Lorè; Camilla Riva; Ida De Fino; Lorenza Spagnuolo; Barbara Sipione; Giacomo Rossi; Alessandro Nonis; Giulio Cabrini; Alessandra Bragonzi
Journal:  Sci Rep       Date:  2016-02-17       Impact factor: 4.379
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  10 in total

1.  Differential In Vitro Activities of Individual Drugs and Bedaquiline-Rifabutin Combinations against Actively Multiplying and Nutrient-Starved Mycobacterium abscessus.

Authors:  Jin Lee; Nicole Ammerman; Anusha Agarwal; Maram Naji; Si-Yang Li; Eric Nuermberger
Journal:  Antimicrob Agents Chemother       Date:  2021-01-20       Impact factor: 5.191

2.  In Vitro Activity of Bedaquiline and Imipenem against Actively Growing, Nutrient-Starved, and Intracellular Mycobacterium abscessus.

Authors:  Olumide Martins; Jin Lee; Amit Kaushik; Nicole C Ammerman; Kelly E Dooley; Eric L Nuermberger
Journal:  Antimicrob Agents Chemother       Date:  2021-09-13       Impact factor: 5.191

Review 3.  Pipeline of anti-Mycobacterium abscessus small molecules: Repurposable drugs and promising novel chemical entities.

Authors:  Anna Egorova; Mary Jackson; Victor Gavrilyuk; Vadim Makarov
Journal:  Med Res Rev       Date:  2021-03-01       Impact factor: 12.388

4.  Potency of Omadacycline against Mycobacteroides abscessus Clinical Isolates In Vitro and in a Mouse Model of Pulmonary Infection.

Authors:  Emily C Maggioncalda; Elizabeth Story-Roller; Danielle A Nicklas; Benjamin Eichelman; Chavis Tabor; Alisa W Serio; Tiffany R Keepers; Surya Chitra; Gyanu Lamichhane
Journal:  Antimicrob Agents Chemother       Date:  2021-10-18       Impact factor: 5.191

5.  Mycobacteriophage-antibiotic therapy promotes enhanced clearance of drug-resistant Mycobacterium abscessus.

Authors:  Matt D Johansen; Matthéo Alcaraz; Rebekah M Dedrick; Françoise Roquet-Banères; Claire Hamela; Graham F Hatfull; Laurent Kremer
Journal:  Dis Model Mech       Date:  2021-09-16       Impact factor: 5.758

6.  Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish.

Authors:  Julia Y Kam; Elinor Hortle; Elizabeth Krogman; Sherridan E Warner; Kathryn Wright; Kaiming Luo; Tina Cheng; Pradeep Manuneedhi Cholan; Kazu Kikuchi; James A Triccas; Warwick J Britton; Matt D Johansen; Laurent Kremer; Stefan H Oehlers
Journal:  Nat Commun       Date:  2022-02-17       Impact factor: 14.919

7.  The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness.

Authors:  Marion Lagune; Vincent Le Moigne; Matt D Johansen; Flor Vásquez Sotomayor; Wassim Daher; Cécile Petit; Gina Cosentino; Laura Paulowski; Thomas Gutsmann; Matthias Wilmanns; Florian P Maurer; Jean-Louis Herrmann; Fabienne Girard-Misguich; Laurent Kremer
Journal:  PLoS Pathog       Date:  2022-08-12       Impact factor: 7.464

8.  Activity of Drug Combinations against Mycobacterium abscessus Grown in Aerobic and Hypoxic Conditions.

Authors:  Alessio Lanni; Emanuele Borroni; Angelo Iacobino; Cristina Russo; Leonarda Gentile; Lanfranco Fattorini; Federico Giannoni
Journal:  Microorganisms       Date:  2022-07-14

9.  A New Model of Chronic Mycobacterium abscessus Lung Infection in Immunocompetent Mice.

Authors:  Camilla Riva; Enrico Tortoli; Federica Cugnata; Francesca Sanvito; Antonio Esposito; Marco Rossi; Anna Colarieti; Tamara Canu; Cristina Cigana; Alessandra Bragonzi; Nicola Ivan Loré; Paolo Miotto; Daniela Maria Cirillo
Journal:  Int J Mol Sci       Date:  2020-09-09       Impact factor: 5.923

10.  Efficacy estimation of a combination of triple antimicrobial agents against clinical isolates of Mycobacterium abscessus subsp. abscessus in vitro.

Authors:  Takahiro Asami; Akio Aono; Kinuyo Chikamatsu; Yuriko Igarashi; Yuta Morishige; Yoshiro Murase; Hiroyuki Yamada; Akiko Takaki; Satoshi Mitarai
Journal:  JAC Antimicrob Resist       Date:  2021-02-19
  10 in total

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