Panagiotis Anagnostis1, Patroklos Theocharis2, Konstantinos Lallas3, Georgios Konstantis3, Konstantinos Mastrogiannis3, Julia K Bosdou3, Irene Lambrinoudaki4, John C Stevenson5, Dimitrios G Goulis3. 1. 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece; Police Medical Center of Thessaloniki, Thessaloniki, Greece. Electronic address: pan.anagnostis@gmail.com. 2. 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece; Police Medical Center of Thessaloniki, Thessaloniki, Greece. 3. 1st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. 4. 2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Medical School, Athens, Greece. 5. National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield NHS Foundation Trust, London, SW3 6NP, UK.
Abstract
OBJECTIVE: Menopausal transition has been associated with an increased risk of cardiovascular disease (CVD), mainly attributed to atherogenic dyslipidaemia, central obesity and insulin resistance. Whether arterial hypertension (AH) also contributes to menopause-associated CVD is currently unknown. The aim of this study was to systematically investigate and meta-analyze the best available evidence regarding the association between early menopause (EM) and AH risk. METHODS: A comprehensive search was conducted in PubMed, CENTRAL and Scopus databases, up to January 20th, 2020. Data were expressed as odds ratio (OR) with 95 % confidence intervals (CI). The I2 index was employed for heterogeneity. RESULTS: Ten studies were included in the quantitative analysis (273,994 postmenopausal women, 76853 cases with AH). Women with EM (age at menopause <45 years) were at higher AH risk compared with those of normal age at menopause (>45 years) (OR 1.10, 95 % CI 1.01-1.19, p = 0.03; I2 79 %). The direction or the magnitude of this association remained significant when the analysis was restricted to studies including groups matched for potential confounders, such as age, BMI, smoking or the use of menopausal hormone therapy or oral contraceptives. CONCLUSIONS: Women with EM have an increased risk for AH compared with those of normal age at menopause.
OBJECTIVE: Menopausal transition has been associated with an increased risk of cardiovascular disease (CVD), mainly attributed to atherogenic dyslipidaemia, central obesity and insulin resistance. Whether arterial hypertension (AH) also contributes to menopause-associated CVD is currently unknown. The aim of this study was to systematically investigate and meta-analyze the best available evidence regarding the association between early menopause (EM) and AH risk. METHODS: A comprehensive search was conducted in PubMed, CENTRAL and Scopus databases, up to January 20th, 2020. Data were expressed as odds ratio (OR) with 95 % confidence intervals (CI). The I2 index was employed for heterogeneity. RESULTS: Ten studies were included in the quantitative analysis (273,994 postmenopausal women, 76853 cases with AH). Women with EM (age at menopause <45 years) were at higher AH risk compared with those of normal age at menopause (>45 years) (OR 1.10, 95 % CI 1.01-1.19, p = 0.03; I2 79 %). The direction or the magnitude of this association remained significant when the analysis was restricted to studies including groups matched for potential confounders, such as age, BMI, smoking or the use of menopausal hormone therapy or oral contraceptives. CONCLUSIONS:Women with EM have an increased risk for AH compared with those of normal age at menopause.
Authors: Thayza de Paula Araújo; Lucas Gabriel Sulino Borges; Weimar Kunz Sebba Barroso; Andrea Araújo Brandão; Eduardo Costa Duarte Barbosa; Audes Diógenes M Feitosa; Marcus Vinícius Bolivar Malachias; Marco Mota Gomes; Celso Amodeo; Rui Manoel Dos Santos Povoa; Paulo César Brandão Veiga Jardim; Renato D Lopes; Sandro Rogério Rodrigues Batista; Priscila Valverde de Oliveira Vitorino Journal: J Clin Hypertens (Greenwich) Date: 2022-06-30 Impact factor: 2.885
Authors: Angela H E M Maas; Giuseppe Rosano; Renata Cifkova; Alaide Chieffo; Dorenda van Dijken; Haitham Hamoda; Vijay Kunadian; Ellen Laan; Irene Lambrinoudaki; Kate Maclaran; Nick Panay; John C Stevenson; Mick van Trotsenburg; Peter Collins Journal: Eur Heart J Date: 2021-03-07 Impact factor: 29.983
Authors: Zayne M Roa-Díaz; Eralda Asllanaj; Hasnat A Amin; Lyda Z Rojas; Jana Nano; Mohammad Arfan Ikram; Fotios Drenos; Oscar H Franco; Raha Pazoki; Pedro Marques-Vidal; Trudy Voortman; Taulant Muka Journal: J Clin Med Date: 2021-09-22 Impact factor: 4.241