OBJECTIVES: African American (AA) women with breast cancer (BrCA) have higher mortality than any other race. Differential mortality has been attributed to nonadherence to endocrine therapy (ET). ET can lower the risk of dying by one third; yet 50% to 75% of all women are nonadherent to ET. Despite the wealth of research examining adherence to ET, understanding which groups of women at risk for poor adherence is not well established. The aim of this investigation was to describe ET adherence by race and geographic location among a cohort of younger BrCA survivors. MATERIALS AND METHODS: Cancer registry records were linked to administrative data from Medicaid and a private insurance plan in South Carolina. Inclusion criteria included: European American (EA) or AA race, 3 years of continuous enrollment in the insurance plan after diagnosis, and BrCA diagnosis between 2002 and 2010. Adherence was measured by computing a medication possession ratio (MPR) based upon refill service dates and the number of pills dispensed. Adjusted least squared means were calculated by racial and geographic group using analysis of covariance methods. RESULTS: The average MPR for EA women was significantly higher at 96% compared with 92% for AA women (P<0.01). After adjustment for years on hormone therapy, age, and number of pharmacies utilized, rural AA women had an average MPR of 90% compared with 95% for EA women (P<0.01). CONCLUSIONS: AA women residing in rural areas demonstrate significantly lower adherence compared with their EA counterparts. Interventions are needed to improve adherence that may ameliorate AA mortality disparities.
OBJECTIVES: African American (AA) women with breast cancer (BrCA) have higher mortality than any other race. Differential mortality has been attributed to nonadherence to endocrine therapy (ET). ET can lower the risk of dying by one third; yet 50% to 75% of all women are nonadherent to ET. Despite the wealth of research examining adherence to ET, understanding which groups of women at risk for poor adherence is not well established. The aim of this investigation was to describe ET adherence by race and geographic location among a cohort of younger BrCA survivors. MATERIALS AND METHODS: Cancer registry records were linked to administrative data from Medicaid and a private insurance plan in South Carolina. Inclusion criteria included: European American (EA) or AA race, 3 years of continuous enrollment in the insurance plan after diagnosis, and BrCA diagnosis between 2002 and 2010. Adherence was measured by computing a medication possession ratio (MPR) based upon refill service dates and the number of pills dispensed. Adjusted least squared means were calculated by racial and geographic group using analysis of covariance methods. RESULTS: The average MPR for EA women was significantly higher at 96% compared with 92% for AA women (P<0.01). After adjustment for years on hormone therapy, age, and number of pharmacies utilized, rural AA women had an average MPR of 90% compared with 95% for EA women (P<0.01). CONCLUSIONS: AA women residing in rural areas demonstrate significantly lower adherence compared with their EA counterparts. Interventions are needed to improve adherence that may ameliorate AA mortality disparities.
Authors: Susan B Kesmodel; Olga G Goloubeva; Paula Y Rosenblatt; Brian Heiss; Emily C Bellavance; Saranya Chumsri; Ting Bao; Jennifer Thompson; Ginah Nightingale; Nancy S Tait; Elizabeth M Nichols; Steve J Feigenberg; Katherine H Tkaczuk Journal: Am J Clin Oncol Date: 2018-05 Impact factor: 2.339
Authors: Stephanie Brooke Wheeler; Racquel Elizabeth Kohler; Katherine Elizabeth Reeder-Hayes; Ravi K Goyal; Kristen Hassmiller Lich; Alexis Moore; Timothy W Smith; Cathy L Melvin; Hyman Bernard Muss Journal: J Cancer Surviv Date: 2014-05-28 Impact factor: 4.442
Authors: Dawn L Hershman; Theresa Shao; Lawrence H Kushi; Donna Buono; Wei Yann Tsai; Louis Fehrenbacher; Marilyn Kwan; Scarlett Lin Gomez; Alfred I Neugut Journal: Breast Cancer Res Treat Date: 2010-08-28 Impact factor: 4.872
Authors: Joyce A Cramer; Anuja Roy; Anita Burrell; Carol J Fairchild; Mahesh J Fuldeore; Daniel A Ollendorf; Peter K Wong Journal: Value Health Date: 2008 Jan-Feb Impact factor: 5.725
Authors: Courtney P Williams; Amy Davidoff; Michael T Halpern; Michelle Mollica; Kathleen Castro; Benjamin Allaire; Janet S de Moor Journal: JCO Oncol Pract Date: 2022-08
Authors: Cameron B Haas; Erin J Aiello Bowles; Janie M Lee; Jennifer Specht; Diana S M Buist Journal: Cancer Causes Control Date: 2022-07-07 Impact factor: 2.532
Authors: Erin J Aiello Bowles; Cody Ramin; Diana S M Buist; Heather Spencer Feigelson; Sheila Weinmann; Lene H S Veiga; Clara Bodelon; Rochelle E Curtis; Jacqueline B Vo; Amy Berrington de Gonzalez; Gretchen L Gierach Journal: Breast Cancer Res Treat Date: 2022-03-11 Impact factor: 4.872
Authors: Whitney E Zahnd; Cathryn Murphy; Marie Knoll; Gabriel A Benavidez; Kelsey R Day; Radhika Ranganathan; Parthenia Luke; Anja Zgodic; Kewei Shi; Melinda A Merrell; Elizabeth L Crouch; Heather M Brandt; Jan M Eberth Journal: Int J Environ Res Public Health Date: 2021-02-03 Impact factor: 3.390
Authors: Jessica E Hawley; Tianyi Sun; David D Chism; Narjust Duma; Julie C Fu; Na Tosha N Gatson; Sanjay Mishra; Ryan H Nguyen; Sonya A Reid; Oscar K Serrano; Sunny R K Singh; Neeta K Venepalli; Ziad Bakouny; Babar Bashir; Mehmet A Bilen; Paolo F Caimi; Toni K Choueiri; Scott J Dawsey; Leslie A Fecher; Daniel B Flora; Christopher R Friese; Michael J Glover; Cyndi J Gonzalez; Sharad Goyal; Thorvardur R Halfdanarson; Dawn L Hershman; Hina Khan; Chris Labaki; Mark A Lewis; Rana R McKay; Ian Messing; Nathan A Pennell; Matthew Puc; Deepak Ravindranathan; Terence D Rhodes; Andrea V Rivera; John Roller; Gary K Schwartz; Sumit A Shah; Justin A Shaya; Mitrianna Streckfuss; Michael A Thompson; Elizabeth M Wulff-Burchfield; Zhuoer Xie; Peter Paul Yu; Jeremy L Warner; Dimpy P Shah; Benjamin French; Clara Hwang Journal: JAMA Netw Open Date: 2022-01-04
Authors: Xin Hu; Mark S Walker; Edward Stepanski; Cameron M Kaplan; Michelle Y Martin; Gregory A Vidal; Lee S Schwartzberg; Ilana Graetz Journal: JAMA Netw Open Date: 2022-08-01
Authors: Zerko Wako; Daniel Mengistu; Negalign Getahun Dinegde; Tseganesh Asefa; Mulugeta Wassie Journal: Breast Cancer (Dove Med Press) Date: 2021-06-09