Xinyu Zhao1, Na Wang2, Yuanyuan Sun1, Guoling Zhu3, Yanhong Wang1, Zhenyu Wang1, Yanmin Zhang3, Kailiang Cheng1, Guodong Wang4, Shouling Wu5, Li Wang1. 1. Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China. 2. Department of cardiology, the second hospital of Qinhuangdao, Qinhuangdao, China. 3. Department of Gastroenterology, Kailuan General Hospital, Tangshan, China. 4. Department of Employee Health Protection, Tangshan, China. 5. Department of cardiology, Kailuan General Hospital, Tangshan, China.
Abstract
BACKGROUND: Few studies have examined the risk of gastrointestinal cancers in screen-detected gallstone disease. This study aimed to investigate the association between screen-detected gallstone disease and gastrointestinal cancers using the Kailuan cohort, a population-based prospective cohort initiated in 2006. METHODS: A total of 79 809 men who underwent gallbladder ultrasonography, were free of cancers in 2006 and did not have gastrointestinal cancers within one year were enrolled. A Cox proportional hazards model with age as the timescale was used to evaluate the association between screen-detected gallstone disease and gastrointestinal cancers. RESULTS: We identified 1264 cases with gastrointestinal cancers, including 303 cases with liver cancer and 94 cases with pancreatic cancer. Screen-detected gallstone disease increased the risk of liver cancer, with an HR of 2.28 [95% confidence interval (CI): 1.20-4.33, P = .012]. The association was modified by the hepatitis B surface antigen status. A non-significant positive association was observed between pancreatic cancer and gallstone disease (HR 2.19, 95% CI: 0.95-5.05, P = .065). However, the HR became significant after those individuals with diabetes were excluded (HR 2.60, 95% CI: 1.12-6.01, P = .026). CONCLUSION: Screen-detected gallstone disease may predict the risk for liver and pancreatic cancer.
BACKGROUND: Few studies have examined the risk of gastrointestinal cancers in screen-detected gallstone disease. This study aimed to investigate the association between screen-detected gallstone disease and gastrointestinal cancers using the Kailuan cohort, a population-based prospective cohort initiated in 2006. METHODS: A total of 79 809 men who underwent gallbladder ultrasonography, were free of cancers in 2006 and did not have gastrointestinal cancers within one year were enrolled. A Cox proportional hazards model with age as the timescale was used to evaluate the association between screen-detected gallstone disease and gastrointestinal cancers. RESULTS: We identified 1264 cases with gastrointestinal cancers, including 303 cases with liver cancer and 94 cases with pancreatic cancer. Screen-detected gallstone disease increased the risk of liver cancer, with an HR of 2.28 [95% confidence interval (CI): 1.20-4.33, P = .012]. The association was modified by the hepatitis B surface antigen status. A non-significant positive association was observed between pancreatic cancer and gallstone disease (HR 2.19, 95% CI: 0.95-5.05, P = .065). However, the HR became significant after those individuals with diabetes were excluded (HR 2.60, 95% CI: 1.12-6.01, P = .026). CONCLUSION: Screen-detected gallstone disease may predict the risk for liver and pancreatic cancer.
Authors: Xiao Luo; Wanshui Yang; Amit D Joshi; Kana Wu; Tracey G Simon; Chen Yuan; Lina Jin; Lu Long; Mi Na Kim; Chun-Han Lo; Xing Liu; Thomas A Abrams; Brian M Wolpin; Andrew T Chan; Edward L Giovannucci; Xuehong Zhang Journal: Br J Cancer Date: 2022-06-17 Impact factor: 9.075