Literature DB >> 32249682

Cannabinoids as anticancer therapeutic agents.

Olga Kovalchuk1,2, Igor Kovalchuk1,2.   

Abstract

The recent announcement of marijuana legalization in Canada spiked many discussions about potential health benefits of Cannabis sativa. Cannabinoids are active chemical compounds produced by cannabis, and their numerous effects on the human body are primarily exerted through interactions with cannabinoid receptor types 1 (CB1) and 2 (CB2). Cannabinoids are broadly classified as endo-, phyto-, and synthetic cannabinoids. In this review, we will describe the activity of cannabinoids on the cellular level, comprehensively summarize the activity of all groups of cannabinoids on various cancers and propose several potential mechanisms of action of cannabinoids on cancer cells.

Entities:  

Keywords:  Cannabinoids; anti-tumor activity; cancer; cannabidiol; tetrahydrocannabinol

Year:  2020        PMID： 32249682      PMCID： PMC7217364          DOI： 10.1080/15384101.2020.1742952

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  184 in total

Review 1.  Concomitant consumption of marijuana, alcohol and tobacco in oral squamous cell carcinoma development and progression: recent advances and challenges.

Authors:  Caio Fabio Baeta Lopes; Bruno Brandão de Angelis; Henrique Maciel Prudente; Bernardo Vieira Goulart de Souza; Sérgio Vitorino Cardoso; Rosy Iara Maciel de Azambuja Ribeiro
Journal:  Arch Oral Biol       Date:  2012-06-22       Impact factor: 2.633

2.  CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum.

Authors:  E Martínez-Pinilla; I Reyes-Resina; A Oñatibia-Astibia; M Zamarbide; A Ricobaraza; G Navarro; E Moreno; I G Dopeso-Reyes; S Sierra; A J Rico; E Roda; J L Lanciego; R Franco
Journal:  Exp Neurol       Date:  2014-06-23       Impact factor: 5.330

3.  Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1).

Authors:  C J Hillard; S Manna; M J Greenberg; R DiCamelli; R A Ross; L A Stevenson; V Murphy; R G Pertwee; W B Campbell
Journal:  J Pharmacol Exp Ther       Date:  1999-06       Impact factor: 4.030

4.  Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233.

Authors:  Steven N Gurley; Ammaar H Abidi; Patrick Allison; Peihong Guan; Christopher Duntsch; Jon H Robertson; Stanley D Kosanke; Stephen T Keir; Darell D Bigner; Andrea J Elberger; Bob M Moore
Journal:  J Neurooncol       Date:  2012-08-09       Impact factor: 4.130

Review 5.  Antitumorigenic effects of cannabinoids beyond apoptosis.

Authors:  Nadine Freimuth; Robert Ramer; Burkhard Hinz
Journal:  J Pharmacol Exp Ther       Date:  2009-11-04       Impact factor: 4.030

Review 6.  Cannabinoid receptors: where they are and what they do.

Authors:  K Mackie
Journal:  J Neuroendocrinol       Date:  2008-05       Impact factor: 3.627

7.  Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo.

Authors:  A Preet; R K Ganju; J E Groopman
Journal:  Oncogene       Date:  2007-07-09       Impact factor: 9.867

8.  The profile of immune modulation by cannabidiol (CBD) involves deregulation of nuclear factor of activated T cells (NFAT).

Authors:  Barbara L F Kaplan; Alison E B Springs; Norbert E Kaminski
Journal:  Biochem Pharmacol       Date:  2008-07-08       Impact factor: 5.858

9.  Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon.

Authors:  Angelo A Izzo; Gabriella Aviello; Stefania Petrosino; Pierangelo Orlando; Giovanni Marsicano; Beat Lutz; Francesca Borrelli; Raffaele Capasso; Santosh Nigam; Francesco Capasso; Vincenzo Di Marzo
Journal:  J Mol Med (Berl)       Date:  2007-09-06       Impact factor: 4.599

10.  Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer.

Authors:  Gemma Navarro; Paulina Carriba; Jorge Gandía; Francisco Ciruela; Vicent Casadó; Antoni Cortés; Josefa Mallol; Enric I Canela; Carmen Lluis; Rafael Franco
Journal:  ScientificWorldJournal       Date:  2008-10-11
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  19 in total

1.  Acute Cannabigerol Administration Lowers Blood Pressure in Mice.

Authors:  Victoria L Vernail; Sarah S Bingaman; Yuval Silberman; Wesley M Raup-Konsavage; Kent E Vrana; Amy C Arnold
Journal:  Front Physiol       Date:  2022-05-09       Impact factor: 4.755

2.  Anticancer and chemosensitization effects of cannabidiol in 2D and 3D cultures of TNBC: involvement of GADD45α, integrin-α5, -β5, -β1, and autophagy.

Authors:  Sunil Kumar Surapaneni; Nilkumar Patel; Li Sun; Nagavendra Kommineni; Anil Kumar Kalvala; Aragaw Gebeyehu; Peggy Arthur; Leanne C Duke; Ramesh Nimma; David G Meckes; Mandip Singh
Journal:  Drug Deliv Transl Res       Date:  2022-02-25       Impact factor: 5.671

3.  Cannabinoids orchestrate cross-talk between cancer cells and endothelial cells in colorectal cancer.

Authors:  Cong-Kai Luo; Pei-Hsuan Chou; Shang-Kok Ng; Wen-Yen Lin; Tzu-Tang Wei
Journal:  Cancer Gene Ther       Date:  2021-05-18       Impact factor: 5.987

Review 4.  Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective.

Authors:  Santosh V Suryavanshi; Igor Kovalchuk; Olga Kovalchuk
Journal:  Front Immunol       Date:  2021-01-28       Impact factor: 7.561

5.  In search of preventive strategies: novel high-CBD Cannabis sativa extracts modulate ACE2 expression in COVID-19 gateway tissues.

Authors:  Bo Wang; Anna Kovalchuk; Dongping Li; Rocio Rodriguez-Juarez; Yaroslav Ilnytskyy; Igor Kovalchuk; Olga Kovalchuk
Journal:  Aging (Albany NY)       Date:  2020-11-22       Impact factor: 5.682

Review 6.  A narrative review of the ethnomedicinal usage of Cannabis sativa Linnaeus as traditional phytomedicine by folk medicine practitioners of Bangladesh.

Authors:  Shahriar S M Shakil; Matt Gowan; Kerry Hughes; Md Nur Kabidul Azam; Md Nasir Ahmed
Journal:  J Cannabis Res       Date:  2021-03-19

Review 7.  Applications of Graphene and Graphene Oxide in Smart Drug/Gene Delivery: Is the World Still Flat?

Authors:  Mojtaba Hoseini-Ghahfarokhi; Soroush Mirkiani; Naeimeh Mozaffari; Mohamad Amin Abdolahi Sadatlu; Amir Ghasemi; Somayeh Abbaspour; Mohsen Akbarian; Fatemeh Farjadian; Mahdi Karimi
Journal:  Int J Nanomedicine       Date:  2020-11-27

Review 8.  Neurofibromatosis: Molecular Pathogenesis and Natural Compounds as Potential Treatments.

Authors:  Anusha Amaravathi; Janet L Oblinger; D Bradley Welling; A Douglas Kinghorn; Long-Sheng Chang
Journal:  Front Oncol       Date:  2021-09-17       Impact factor: 6.244

Review 9.  Medical Cannabis in Pediatric Oncology: Friend or Foe?

Authors:  Megan Malach; Igor Kovalchuk; Olga Kovalchuk
Journal:  Pharmaceuticals (Basel)       Date:  2022-03-16

Review 10.  Anti-Microbial Activity of Phytocannabinoids and Endocannabinoids in the Light of Their Physiological and Pathophysiological Roles.

Authors:  Ronit Vogt Sionov; Doron Steinberg
Journal:  Biomedicines       Date:  2022-03-09
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