OBJECTIVE: Thyroid pathology has great potential for automated/artificial intelligence (AI) algorithm application as the incidence of thyroid nodules is increasing and the indeterminate interpretation rate of fine-needle aspiration remains relatively high. The aim of the study is to review the published literature on automated image analysis and AI applications to thyroid pathology with whole-slide imaging (WSI). METHODS: Systematic search was carried out in electronic databases. Studies dealing with thyroid pathology and use of automated algorithms applied to WSI were included. Quality of studies was assessed with a modified QUADAS-2 tool. RESULTS: Of 919 retrieved articles, 19 were included. The main themes addressed were the comparison of automated assessment of immunohistochemical staining with manual pathologist's assessment, quantification of differences in cellular and nuclear parameters among tumor entities, and discrimination between benign and malignant nodules. Correlation coefficients with manual assessment were higher than 0.76 and diagnostic performance of automated models was comparable with an expert pathologist diagnosis. Computational difficulties were related to the large size of whole-slide images. CONCLUSIONS: Overall, the results are promising and it is likely that with the resolution of technical issues the application of automated algorithms in thyroid pathology will increase and be adopted following suitable validation studies. This article is protected by copyright. All rights reserved.
OBJECTIVE: Thyroid pathology has great potential for automated/artificial intelligence (AI) algorithm application as the incidence of thyroid nodules is increasing and the indeterminate interpretation rate of fine-needle aspiration remains relatively high. The aim of the study is to review the published literature on automated image analysis and AI applications to thyroid pathology with whole-slide imaging (WSI). METHODS: Systematic search was carried out in electronic databases. Studies dealing with thyroid pathology and use of automated algorithms applied to WSI were included. Quality of studies was assessed with a modified QUADAS-2 tool. RESULTS: Of 919 retrieved articles, 19 were included. The main themes addressed were the comparison of automated assessment of immunohistochemical staining with manual pathologist's assessment, quantification of differences in cellular and nuclear parameters among tumor entities, and discrimination between benign and malignant nodules. Correlation coefficients with manual assessment were higher than 0.76 and diagnostic performance of automated models was comparable with an expert pathologist diagnosis. Computational difficulties were related to the large size of whole-slide images. CONCLUSIONS: Overall, the results are promising and it is likely that with the resolution of technical issues the application of automated algorithms in thyroid pathology will increase and be adopted following suitable validation studies. This article is protected by copyright. All rights reserved.
Authors: Joseph M Rohr; Maheswari Mukherjee; Amber Donnelly; Sarah Sprinkle; Ernesto Martinez Duarte; Ana Yuil Valdes Journal: J Pathol Inform Date: 2022-07-05